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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
CASH FLOWS FROM OPERATING ACTIVITIES    
Net loss $ (20,080) $ (14,103)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 2,048 1,979
Operating lease right-of-use asset amortization 444 459
Depreciation and amortization 217 130
Amortization of debt issuance costs and accretion of debt discount 45  
Accretion of discount on marketable securities, net of premium amortization (164) (94)
Foreign currency remeasurement loss 549  
Change in deferred tax asset 183 180
Changes in operating assets and liabilities:    
Research and development tax incentive receivable (162) (441)
Receivable from collaboration partner - related party 3,161 (474)
Prepaid expenses and other assets 806 (406)
Accounts payable 913 696
Payable to collaboration partner - related party (146) 150
Accrued expenses and other payables (700) (3,053)
Deferred revenue - related party (2,485) (1,222)
Operating lease liability (477) (463)
Net cash used in operating activities (15,848) (16,662)
CASH FLOWS FROM INVESTING ACTIVITIES    
Purchase of marketable securities (20,883) (21,726)
Proceeds from maturities of marketable securities 63,751 26,000
Purchases of property and equipment (138) (166)
Net cash provided by investing activities 42,730 4,108
CASH FLOWS FROM FINANCING ACTIVITIES    
Issuance costs related to issuance of long-term debt (7)  
Proceeds from issuance of common stock upon exercise of stock options and purchases under employee stock purchase plan 406 390
Net cash provided by financing activities 399 390
Effect of exchange rate changes on cash, cash equivalents and restricted cash (72) 8
Net increase (decrease) in cash, cash equivalents and restricted cash 27,209 (12,156)
Cash, cash equivalents and restricted cash, beginning of period 33,466 82,693
Cash, cash equivalents and restricted cash, end of period 60,675 70,537
SUPPLEMENTAL DISCLOSURES OF NON-CASH FINANCING AND INVESTING INFORMATION:    
Purchases of property and equipment in accounts payable and accrued liabilities $ 5 649
Tenant improvement allowance reimbursement   $ 469