Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
Sep. 30, 2019	Sep. 30, 2018
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (59,686)	$ (25,059)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	6,193	4,847
Operating lease right-of-use asset amortization	1,347
Change in deferred tax asset	(1,548)
Depreciation and amortization	501	399
Net (accretion of discount) amortization of premium on available-for-sale securities	(397)	304
Changes in operating assets and liabilities:
Research and development tax incentive receivable, net	1,237	96
Receivable from collaboration partner - related party	2,642	(2,770)
Prepaid expenses and other assets	(1,586)	526
Accounts payable	(4,165)	3,617
Payable to collaboration partner - related party	(41)	764
Accrued expenses and other payables	(781)	1,246
Operating lease liability	(1,409)
Deferred revenue - related party	30,455	(23,782)
Net cash used in operating activities	(27,238)	(39,812)
CASH FLOWS FROM INVESTING ACTIVITIES
Purchase of available-for-sale securities	(117,807)	(51,947)
Proceeds from maturities of available-for-sale securities	77,400	50,035
Purchases of property and equipment, net	(749)	(424)
Net cash used in investing activities	(41,156)	(2,336)
CASH FLOWS FROM FINANCING ACTIVITIES
Proceeds from issuance of common stock and warrants in private placement, net of issuance costs		21,679
Proceeds from at-the-market offering, net of issuance costs	34,492	1,025
Proceeds from issuance of common stock upon exercise of stock options and purchases under employee stock purchase plan	1,765	932
Net cash provided by financing activities	36,257	23,636
Effect of exchange rate changes on cash, cash equivalents and restricted cash	99	(90)
Net decrease in cash, cash equivalents and restricted cash	(32,038)	(18,602)
Cash, cash equivalents and restricted cash, beginning of period	82,693	106,489
Cash, cash equivalents and restricted cash, end of period	50,655	$ 87,887
SUPPLEMENTAL DISCLOSURES OF NON-CASH FINANCING AND INVESTING INFORMATION:
Purchases of property and equipment in accounts payable and accrued liabilities	$ 157

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Name:	us-gaap_ShareBasedCompensation
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration