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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
CASH FLOWS FROM OPERATING ACTIVITIES    
Net loss $ (25,059) $ (33,905)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:    
Stock-based compensation 4,847 3,052
Net amortization of premium on available-for-sale securities 304 497
Depreciation and amortization 399 289
Loss on disposal of property and equipment   (62)
Changes in operating assets and liabilities:    
Research and development tax incentive receivable 96 1,530
Receivable from collaboration partner - related party (2,770) (520)
Prepaid expenses and other assets 526 1,034
Accounts payable 3,617 1,096
Payable to collaboration partner - related party 764  
Accrued expenses and other payables 1,246 3,271
Deferred revenue - related party (23,782) 41,739
Net cash provided by (used in) operating activities (39,812) 18,021
CASH FLOWS FROM INVESTING ACTIVITIES    
Purchase of available-for-sale securities (51,947) (28,154)
Proceeds from maturities of available-for-sale securities 50,035 39,835
Purchases of property and equipment, net (424) (610)
Net cash (used in) provided by investing activities (2,336) 11,071
CASH FLOWS FROM FINANCING ACTIVITIES    
Proceeds from issuance of common stock and warrants in private placement, net of issuance costs 21,679  
Proceeds from issuance of common stock in at-the-market offerings, net of issuance costs 1,025  
Proceeds from issuance of common stock upon exercise of stock options and purchases under employee stock purchase plan 932 789
Payment of deferred offering costs   (297)
Net cash provided by financing activities 23,636 492
Effect of exchange rate changes on cash, cash equivalents and restricted cash (90) 177
Net increase (decrease) in cash, cash equivalents and restricted cash (18,602) 29,761
Cash, cash equivalents and restricted cash, beginning of year 106,489 21,094
Cash, cash equivalents and restricted cash, end of period $ 87,887 50,855
SUPPLEMENTAL DISCLOSURES OF NON-CASH FINANCING AND INVESTING INFORMATION:    
Acquisition of new equipment upon trade-in for existing equipment   185
Purchases of property and equipment in accounts payable   $ 6