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Janssen Collaboration Agreement (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Jul. 13, 2017
Mar. 31, 2018
Dec. 31, 2018
Dec. 31, 2017
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Transaction price   $ 53,900   $ 53,900
Revenue recognized based on proportional performance   10,500    
License and Collaborative Revenue        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
License and collaboration revenue - related party   $ 10,781    
Collaborative Arrangement, Product        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Development cost   20.00%    
Phase 2 clinical trial | Other services        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
License and collaboration revenue - related party   $ 300    
Janssen Biotech, Inc. | Collaborative Arrangement, Product        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Upfront cash payment $ 50,000      
Development cost   80.00%    
Estimated variable consideration for cost-sharing payments for agreed upon services     $ 3,900  
Janssen Biotech, Inc. | Forecast | Collaborative Arrangement, Product        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Percentage of details provided for PTG-200 to prescribers upon commercial launch     30.00%  
Contingent consideration receivable upon filing of the IND     $ 25,000  
Janssen Biotech, Inc. | Forecast | First Opt-in Election        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Forfeiture of remaining rights and payment of cost, penalty percentage     50.00%  
Future opt-in payment eligible to receive under collaboration arrangement     $ 125,000  
Janssen Biotech, Inc. | Forecast | Second Opt-in Election        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Future opt-in revenue eligible to receive     200,000  
Potential development, regulatory and sales milestone payments     $ 590,000