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Janssen License and Collaboration Agreement (Details) - USD ($)
$ in Millions
3 Months Ended 12 Months Ended
Jul. 13, 2017
Sep. 30, 2017
Dec. 31, 2018
Dec. 31, 2017
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Transaction price   $ 54.3    
Collaborative Arrangement, Product        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Development cost       20.00%
License and collaboration revenue       $ 20.1
First Opt-in Election        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Future opt-in revenue eligible to receive       125.0
Janssen biotech | Collaborative Arrangement, Product        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Upfront cash payment $ 50.0     $ 50.0
Development cost       80.00%
Transaction price       $ 53.9
Decrease in transaction price       0.4
Estimated variable consideration for cost-sharing payments for agreed upon services       3.9
License and collaboration revenue       19.0
Transaction price based on proportional performance       19.0
other services       $ 1.1
Janssen biotech | Forecast | Collaborative Arrangement, Product        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Percentage of details provided for PTG-200 to prescribers upon commercial launch     30.00%  
Contingent consideration receivable     $ 25.0  
Janssen biotech | Forecast | Phase 2 clinical trial        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Future opt-in revenue eligible to receive     $ 25.0  
Janssen biotech | Forecast | First Opt-in Election        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Forfeiture of remaining rights and payment of cost, penalty percentage     50.00%  
Future opt-in payment eligible to receive under collaboration arrangement     $ 125.0  
Janssen biotech | Forecast | Second Opt-in Election        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Future opt-in revenue eligible to receive     200.0  
Potential development, regulatory and sales milestone payments     $ 590.0