240.13d-102 Schedule 13G - Information to be included in statements filed

pursuant to 240.13d-1(b), (c), and (d) and amendments thereto

filed pursuant to 240.13d-2.

Securities and Exchange Commission, Washington, D.C. 20549

Schedule 13G

Under the Securities Exchange Act of 1934

(Amendment No. 2)*

(Name of Issuer)

Protagonist Therapeutics, Inc.

(Title of Class of Securities)

Common Stock, par value $0.00001 per share

(CUSIP Number)

74366E102

(Date of Event Which Requires Filing of this Statement)

December 31, 2022

Check the appropriate box to designate the rule pursuant to which this

Schedule is filed:

[ ] Rule 13d-1(b)

[ x ] Rule 13d-1(c)

[ ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be “filed” for the purpose of Section 18 of the Securities Exchange
Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see
the Notes).

CUSIP No. 74366E102
(1) Names of reporting persons Point72 Asset Management, L.P.
(2) Check the appropriate box if a member of a group	(a)
(see instructions)	(b)X
(3) SEC use only
(4) Citizenship or place of organization Delaware
Number of shares beneficially owned by each reporting person with:
(5) Sole voting power 0
(6) Shared voting power 316,500
(7) Sole dispositive power 0
(8) Shared dispositive power 316,500
(9) Aggregate amount beneficially owned by each reporting person 316,500
(10) Check if the aggregate amount in Row (9) excludes certain shares (see instructions)
(11) Percent of class represented by amount in Row (9) 0.6%
(12) Type of reporting person (see instructions) PN

CUSIP No. 74366E102
(1) Names of reporting persons Point72 Capital Advisors, Inc.
(2) Check the appropriate box if a member of a group	(a)
(see instructions)	(b)X
(3) SEC use only
(4) Citizenship or place of organization Delaware
Number of shares beneficially owned by each reporting person with:
(5) Sole voting power 0
(6) Shared voting power 316,500
(7) Sole dispositive power 0
(8) Shared dispositive power 316,500
(9) Aggregate amount beneficially owned by each reporting person 316,500
(10) Check if the aggregate amount in Row (9) excludes certain shares (see instructions)
(11) Percent of class represented by amount in Row (9) 0.6%
(12) Type of reporting person (see instructions) CO

CUSIP No. 74366E102
(1) Names of reporting persons Cubist Systematic Strategies, LLC
(2) Check the appropriate box if a member of a group	(a)
(see instructions)	(b)X
(3) SEC use only
(4) Citizenship or place of organization Delaware
Number of shares beneficially owned by each reporting person with:
(5) Sole voting power 0
(6) Shared voting power 51,506
(7) Sole dispositive power 0
(8) Shared dispositive power 51,506
(9) Aggregate amount beneficially owned by each reporting person 51,506
(10) Check if the aggregate amount in Row (9) excludes certain shares (see instructions)
(11) Percent of class represented by amount in Row (9) 0.1%
(12) Type of reporting person (see instructions) OO

CUSIP No. 74366E102
(1) Names of reporting persons Steven A. Cohen
(2) Check the appropriate box if a member of a group	(a)
(see instructions)	(b)X
(3) SEC use only
(4) Citizenship or place of organization United States
Number of shares beneficially owned by each reporting person with:
(5) Sole voting power 0
(6) Shared voting power 368,006
(7) Sole dispositive power 0
(8) Shared dispositive power 368,006
(9) Aggregate amount beneficially owned by each reporting person 368,006
(10) Check if the aggregate amount in Row (9) excludes certain shares (see instructions)
(11) Percent of class represented by amount in Row (9) 0.7%
(12) Type of reporting person (see instructions) IN

Item 1(a) Name of issuer:

Protagonist Therapeutics, Inc.

Item 1(b) Address of issuer's principal executive offices:

7707 Gateway Boulevard, Suite 140, Newark, California 94560-1160

2(a) Name of person filing:

This statement is filed by: (i) Point72 Asset Management, L.P. (“Point72 Asset Management”)
with respect to shares of common stock, par value $0.00001 per share (“Shares”), of the Issuer
held by an investment fund it manages; (ii) Point72 Capital Advisors, Inc. (“Point72 Capital
Advisors Inc.”) with respect to Shares held by an investment fund managed by Point72 Asset
Management; (iii) Cubist Systematic Strategies, LLC (“Cubist Systematic Strategies”) with
respect to Shares held by an investment fund it manages; and (iv) Steven A. Cohen
(“Mr. Cohen”) with respect to Shares beneficially owned by Point72 Asset Management,
Point72 Capital Advisors Inc., and Cubist Systematic Strategies.

Point72 Asset Management, Point72 Capital Advisors Inc., Cubist Systematic Strategies, and
Mr. Cohen have entered into a Joint Filing Agreement, a copy of which is filed with this
Schedule 13G as Exhibit 99.1, pursuant to which they have agreed to file this Schedule 13G
jointly in accordance with the provisions of Rule 13d-1(k) of the Act.

2(b) Address or principal business office or, if none, residence:

The address of the principal business office of (i) Point72 Asset Management, Point72 Capital
Advisors Inc., and Mr. Cohen is 72 Cummings Point Road, Stamford, CT 06902; and (ii) Cubist
Systematic Strategies is 55 Hudson Yards, New York, NY 10001.

2(c) Citizenship:

Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a
Delaware corporation. Cubist Systematic Strategies is a Delaware limited liability company.
Mr. Cohen is a United States citizen.

2(d) Title of class of securities:

Common Stock, par value $0.00001 per share

2(e) CUSIP Number:

74366E102

Item 3.

Not applicable

Item 4. Ownership

The information required by Items 4(a) – (c) is set forth in Rows (5) – (11) of the cover page for
each Reporting Person hereto and is incorporated herein by reference for each Reporting Person.
Such information is as of the close of business on December 31, 2022.

Point72 Asset Management, Point72 Capital Advisors Inc., Cubist Systematic Strategies, and
Mr. Cohen own directly no Shares. Pursuant to an investment management agreement, Point72
Asset Management maintains investment and voting power with respect to the securities held by
an investment fund it manages. Point72 Capital Advisors Inc. is the general partner of Point72
Asset Management. Pursuant to an investment management agreement, Cubist Systematic
Strategies maintains investment and voting power with respect to the securities held by an
investment fund it manages. Mr. Cohen controls each of Point72 Asset Management, Point72
Capital Advisors Inc., and Cubist Systematic Strategies. The filing of this statement should not
be construed as an admission that any of the foregoing persons or any reporting person is, for the
purposes of Section 13 of the Act, the beneficial owner of the Shares reported herein.

Item 5. Ownership of 5 Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person has
ceased to be the beneficial owner of more than 5 percent of the class of securities, check the
following [X].

Item 6. Ownership of More than 5 Percent on Behalf of Another Person.

See Item 2(a).

Item 7. Identification and Classification of the Subsidiary

Which Acquired the Security Being Reporting on by the

Parent Holding Company or Control Person.

Not applicable

Item 8. Identification and Classification of Members of the Group

Not applicable

Item 9. Notice of Dissolution of Group.

Not applicable

Item 10. Certifications

By signing below I certify that, to the best of my knowledge and belief, the securities referred to
above were not acquired and are not held for the purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were not acquired and are not held in
connection with or as a participant in any transaction having that purpose or effect.

Signature. After reasonable inquiry and to the best of my knowledge and belief,

I certify that the information set forth in this statement is true, complete

and correct.

Dated: February 14, 2023

POINT72 ASSET MANAGEMENT, L.P.

By: /s/ Jason M. Colombo
Name: Jason M. Colombo
Title: Authorized Person

POINT72 CAPITAL ADVISORS, INC.

By: /s/ Jason M. Colombo
Name: Jason M. Colombo
Title: Authorized Person

CUBIST SYSTEMATIC STRATEGIES, LLC

By: /s/ Jason M. Colombo
Name: Jason M. Colombo
Title: Authorized Person

STEVEN A. COHEN

By: /s/ Jason M. Colombo
Name: Jason M. Colombo
Title: Authorized Person