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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001376355</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001817713</issuerCik>
      <issuerName>Janux Therapeutics, Inc.</issuerName>
      <secFileNumber>001-40475</secFileNumber>
      <issuerAddress>
        <com:street1>10955 VISTA SORRENTO PARKWAY</com:street1>
        <com:street2>SUITE 200</com:street2>
        <com:city>SAN DIEGO</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92130</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(858) 751-4493</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Lichter Jay</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>FORMER DIRECTOR</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Services</name>
        <address>
          <com:street1>200 W Civic Center Dr - 4th Floor</com:street1>
          <com:city>Sandy</com:city>
          <com:stateOrCountry>UT</com:stateOrCountry>
          <com:zipCode>84070</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>3419</noOfUnitsSold>
      <aggregateMarketValue>182954.07</aggregateMarketValue>
      <noOfUnitsOutstanding>52200000</noOfUnitsOutstanding>
      <approxSaleDate>10/28/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>10/28/2024</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK OPTION EXERCISE</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>3281</amountOfSecuritiesAcquired>
      <paymentDate>10/28/2024</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>07/19/2024</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>138</amountOfSecuritiesAcquired>
      <paymentDate>07/19/2024</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>STOCK OPTION EXERCISE</securitiesClassTitle>
      <saleDate>10/21/2024</saleDate>
      <amountOfSecuritiesSold>2336</amountOfSecuritiesSold>
      <grossProceeds>115607.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200,</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>RESTICTED STOCK</securitiesClassTitle>
      <saleDate>10/21/2024</saleDate>
      <amountOfSecuritiesSold>98</amountOfSecuritiesSold>
      <grossProceeds>4847.08</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200,,</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>STOCK OPTION EXERCISE</securitiesClassTitle>
      <saleDate>10/17/2024</saleDate>
      <amountOfSecuritiesSold>1769</amountOfSecuritiesSold>
      <grossProceeds>88479.93</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>RESTICTED STOCK</securitiesClassTitle>
      <saleDate>10/17/2024</saleDate>
      <amountOfSecuritiesSold>74</amountOfSecuritiesSold>
      <grossProceeds>3713.09</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200,</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>STOCK OPTION EXERCISE</securitiesClassTitle>
      <saleDate>10/16/2024</saleDate>
      <amountOfSecuritiesSold>10515</amountOfSecuritiesSold>
      <grossProceeds>534037.40</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>RESTICTED STOCK</securitiesClassTitle>
      <saleDate>10/16/2024</saleDate>
      <amountOfSecuritiesSold>442</amountOfSecuritiesSold>
      <grossProceeds>22561.89</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200,</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>RESTICTED STOCK</securitiesClassTitle>
      <saleDate>09/30/2024</saleDate>
      <amountOfSecuritiesSold>39</amountOfSecuritiesSold>
      <grossProceeds>1805.90</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>STOCK OPTION EXERCISE</securitiesClassTitle>
      <saleDate>09/30/2024</saleDate>
      <amountOfSecuritiesSold>919</amountOfSecuritiesSold>
      <grossProceeds>42496.40</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200,</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>STOCK OPTION EXERCISE</securitiesClassTitle>
      <saleDate>09/27/2024</saleDate>
      <amountOfSecuritiesSold>1752</amountOfSecuritiesSold>
      <grossProceeds>80920.15</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>RESTICTED STOCK</securitiesClassTitle>
      <saleDate>09/27/2024</saleDate>
      <amountOfSecuritiesSold>74</amountOfSecuritiesSold>
      <grossProceeds>3414.36</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200,</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>STOCK OPTION EXERCISE</securitiesClassTitle>
      <saleDate>09/13/2024</saleDate>
      <amountOfSecuritiesSold>3815</amountOfSecuritiesSold>
      <grossProceeds>178084.20</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200,,</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>RESTICTED STOCK</securitiesClassTitle>
      <saleDate>09/09/2024</saleDate>
      <amountOfSecuritiesSold>83</amountOfSecuritiesSold>
      <grossProceeds>3518.04</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200,,</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>STOCK OPTION EXERCISE</securitiesClassTitle>
      <saleDate>09/09/2024</saleDate>
      <amountOfSecuritiesSold>2099</amountOfSecuritiesSold>
      <grossProceeds>88850.67</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200,,</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>STOCK OPTION EXERCISE</securitiesClassTitle>
      <saleDate>10/24/2024</saleDate>
      <amountOfSecuritiesSold>4722</amountOfSecuritiesSold>
      <grossProceeds>251964.45</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>JAY LICHTER</name>
        <address>
          <com:street1>10955 VISTA SORRENTO PARKWAY SUITE 200</com:street1>
          <com:city>SAN DIEGO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>RESTRICTED STOCK</securitiesClassTitle>
      <saleDate>10/24/2024</saleDate>
      <amountOfSecuritiesSold>199</amountOfSecuritiesSold>
      <grossProceeds>10688.73</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>10/28/2024</noticeDate>
      <signature>/s/ Jay Benjamin Lichter</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
