X0306 4 2021-02-23 0 0001493566 OTONOMY, INC. OTIC 0001376355 Lichter Jay C/O OTONOMY, INC. 4796 EXECUTIVE DRIVE SAN DIEGO CA 92121 1 0 0 0 Common Stock 2021-02-23 4 S 0 173005 2.888 D 1309383 I See footnote Common Stock 2021-02-24 4 S 0 324651 2.982 D 984732 I See footnote Common Stock 2021-02-25 4 S 0 200739 2.954 D 783993 I See footnote Common Stock 2021-02-23 4 S 0 95113 2.888 D 719860 I See footnote Common Stock 2021-02-24 4 S 0 178484 2.982 D 541376 I See footnote Common Stock 2021-02-25 4 S 0 110361 2.954 D 431015 I See footnote This sale price represents the weighted average sale price of the shares sold ranging from $2.875 to $2.945 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Holder will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. Shares are held by Avalon Ventures VIII, L.P. ("Avalon VIII"). The Reporting Person is a managing director of Avalon VIII and shares voting and dispositive power with respect to these shares. This sale price represents the weighted average sale price of the shares sold ranging from $2.82 to $3.14 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Holder will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. This sale price represents the weighted average sale price of the shares sold ranging from $2.895 to $3.02 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Holder will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. Shares are held by Avalon Ventures X, L.P. ("Avalon X"). The Reporting Person is a managing director of Avalon X and shares voting and dispositive power with respect to these shares. /s/ Paul E. Cayer, Attorney-in-fact 2021-02-25