SCHEDULE 13G 0001595855 XXXXXXXX LIVE Common Stock 08/29/2025 0001374690 Larimar Therapeutics, Inc. 517125100 Three Bala Plaza East. Suite 506 Bala Cynwyd PA 19004 Rule 13d-1(c) Opaleye Management, Inc. MA 0.00 4110000.00 0.00 4110000.00 4110000.00 N 4.80 IA CO This Schedule 13G amendment is being filed voluntarily. Opaleye, L.P. MA 0.00 4110000.00 0.00 4110000.00 4110000.00 N 4.80 OO This Schedule 13G amendment is being filed voluntarily. James Silverman X1 0.00 4110000.00 0.00 4110000.00 4110000.00 N 4.80 IN This Schedule 13G amendment is being filed voluntarily. Larimar Therapeutics, Inc. Three Bala Plaza East. Suite 506, Bala Cynwyd, PA, 19004 Opaleye Management, Inc. Opaleye, L.P. James Silverman This statement is filed by (i) Opaleye Management, Inc. (the "Adviser"), (ii) Opaleye, L.P. (the "Fund") and (iii) James Silverman with respect to shares directly held by the Fund. The Adviser serves as investment adviser to the Fund. Mr. Silverman exercises control over the Adviser. The filing of this statement should not be construed as an admission that any of the foregoing persons is, for the purposes of Section 13 of the Securities Exchange Act, the beneficial owner of the shares reported herein. One Boston Place, 26th Floor, Boston, MA 02108 Opaleye Management, Inc. - Massachusetts Opaleye, L.P. - Massachusetts James Silverman - USA Y 4,110,000.00 4.80% 0 4,110,000.00 0 4,110,000.00 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 Joint Filing Agreement by and among the reporting persons Opaleye Management, Inc. /s/ James Silverman 08/29/2025 Opaleye, L.P. /s/ James Silverman 08/29/2025 James Silverman /s/ James Silverman 08/29/2025