X0306 4 2019-06-26 0 0001374690 ZAFGEN, INC. ZFGN 0001242616 THOMAS FRANK E C/O ZAFGEN, INC., 3 CENTER PLAZA, SUITE 610 BOSTON MA 02108 1 0 0 0 Stock Option (Right to Buy) 1.25 2019-06-26 4 A 0 27000 0.00 A 2029-06-26 Common Stock 27000 27000 D These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 26, 2020 or the date of the 2020 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company. /s/ Shoaib Ghias, as Attorney-In-Fact 2019-06-27