X0306 4 2018-06-06 0 0001374690 ZAFGEN, INC. ZFGN 0001742622 EVERETT WENDY C/O ZAFGEN, INC., 175 PORTLAND STREET BOSTON MA 02114 1 0 0 0 Stock Option (Right to Buy) 6.79 2018-06-06 4 A 0 20000 0.00 A 2028-06-06 Common Stock 20000 20000 D Stock Option (Right to Buy) 6.79 2018-06-06 4 A 0 40000 0.00 A 2028-06-06 Common Stock 40000 40000 D These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 6, 2019 or the date of the 2019 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company. These options were issued under the nonemployee director compensation policy and will vest monthly over a three year period beginning on the grant date subject to the director's continued service on the board of directors, and provided that, all shares shall become fully vested upon a change in control of the Company. /s/ Shoaib Ghias, Attorney-In-Fact 2018-06-07