X0306 4 2018-01-03 0 0001374690 ZAFGEN, INC. ZFGN 0001538894 Daniel Thomas O C/O ZAFGEN, INC., 175 PORTLAND STREET, 4TH FLOOR BOSTON MA 02114 1 0 0 0 Common Stock 2018-01-03 4 A 0 8687 5.18 A 19452 D The common stock was issued in lieu of cash fees under the Non-Employee Director Compensation Policy pursuant to a Restricted Stock Agreement and the restrictions lapse over a period of one year starting January 1, 2018 on quarterly basis in arrears. /s/ Laurie Burlingame (Attorney-In-Fact) 2018-01-05