X0306 4 2016-03-31 0 0001374690 ZAFGEN, INC. ZFGN 0001348587 Allen Patricia L C/O ZAFGEN, INC. 175 PORTLAND STREET, 4TH FLOOR BOSTON MA 02114 0 1 0 0 Chief Financial Officer Stock Option (Right to Buy) 6.68 2016-03-31 4 A 0 72000 0.00 A 2026-03-31 Common Stock 72000 72000 D Stock Option (Right to Buy) 6.68 2016-03-31 4 A 0 36000 0.00 A 2026-03-31 Common Stock 36000 36000 D 25% of this option vests on March 31, 2017, and the remainder vests in equal monthly installments thereafter over 36 months. This option vests as follows: 25% on March 31, 2017; 25% on September 30, 2017; and 50% on March 31, 2018. /s/ Laurie Burlingame, Attorney-in-Fact 2016-04-04