X0306 4 2015-07-08 0 0001571498 Epizyme, Inc. EPZM 0001374539 Allen Andrew R C/O CLOVIS ONCOLOGY, INC. 2525 28TH STREET, SUITE 100 BOULDER CO 80301 1 0 0 0 Stock Option (Right to Buy) 22.78 2015-07-08 4 A 0 7333 0.00 A 2025-07-07 Common Stock 7333 7333 D This option was granted on July 8, 2015, pursuant to the Company's 2013 Stock Incentive Plan with respect to 7,333 shares of Common Stock and vests in full on July 8, 2016 and, in the event of a change in control of the Company, the vesting will accelerate in full. Exhibit List Exhibit 24 - Confirming Statement /s/ Wenlie Zhou, attorney-in-fact 2015-07-10