SCHEDULE 13G 0001832106 XXXXXXXX LIVE Common Shares, no par value per share 07/29/2025 0001374339 ProMIS Neurosciences Inc. 74346M406 Suite 200, 1920 Yonge Street Toronto A6 M4S 3E2 Rule 13d-1(c) ABG Management Ltd. E9 0.00 6058738.00 0.00 6058738.00 6058738.00 N 11.8 CO Ally Bridge Group (NY) LLC DE 0.00 6058738.00 0.00 6058738.00 6058738.00 N 11.8 OO Limited Liability Company Ally Bridge MedAlpha Master Fund L.P. E9 0.00 6058738.00 0.00 6058738.00 6058738.00 N 11.8 PN Fan Yu O1 0.00 6058738.00 0.00 6058738.00 6058738.00 N 11.8 IN ProMIS Neurosciences Inc. Suite 200, 1920 Yonge Street, Toronto, A6, M4S 3E2 Each of the following is hereinafter individually referred to as a "Reporting Person" and collectively as the "Reporting Persons." This statement is filed on behalf of: ABG Management Ltd. Ally Bridge Group (NY) LLC Ally Bridge MedAlpha Master Fund L.P. Mr. Fan Yu The principal business office address for Ally Bridge Group (NY) LLC is 430 Park Avenue, 12th Floor, New York, NY 10022. The principal business office address for ABG Management Ltd. and Mr. Fan Yu is Unit 3902, 39/F, East Tower Cheung Kong Center II, 10 Harcourt Road Central, Hong Kong. The principal business office address for Ally Bridge MedAlpha Master Fund L.P. is c/o Maples Corporate Services Limited, P.O. Box 309, Ugland House, Grand Cayman, Cayman Islands. Ally Bridge Group (NY) LLC is organized under the laws of the State of Delaware. Mr. Fan Yu is a citizen of Malta. Each of the other Reporting Persons is organized under the laws of the Cayman Islands. Y The information contained on the cover pages of this Schedule 13G is incorporated by reference into this Item 4. The ownership information presented herein represents beneficial ownership of the Issuer's common shares, no par value per share ("Common Shares"), based on 51,511,310 Common Shares outstanding as of July 29, 2025, based on information provided by the Issuer. The Common Shares are held of record by Ally Bridge MedAlpha Master Fund L.P. The amount of securities reported herein does not include 9,690,037 Common Shares issuable upon exercise of warrants held of record by Ally Bridge MedAlpha Master Fund L.P., which are subject to limitations on exercise. Mr. Fan Yu is the controlling stockholder of ABG Management Ltd., which is the sole member of Ally Bridge Group (NY) LLC, which manages the investments of Ally Bridge MedAlpha Master Fund L.P. As such, each of the foregoing entities and Mr. Fan Yu may be deemed to share beneficial ownership of the securities held of record by Ally Bridge MedAlpha Master Fund L.P. Each of them disclaims beneficial ownership of such securities. 11.8 0 6,058,738 0 6,058,738 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 1: Joint Filing Agreement. ABG Management Ltd. By: /s/ Fan Yu 08/04/2025 Ally Bridge Group (NY) LLC By: ABG Management Ltd., its managing member, By: /s/ Fan Yu 08/04/2025 Ally Bridge MedAlpha Master Fund L.P. By: Ally Bridge Group (NY) LLC, its manager, By: ABG Management Ltd., its managing member, By: /s/ Fan Yu 08/04/2025 Fan Yu /s/ Fan Yu 08/04/2025