X0508 4 2025-09-22 0 0001374339 ProMIS Neurosciences Inc. PMN 0001437911 Warma Neil K C/O PROMIS NEUROSCIENCES INC. SUITE 200, 1920 YONGE STREET TORONTO A6 M4S 3E2 ONTARIO, CANADA 1 1 0 0 Chief Executive Officer 0 Option (right to buy) 0.45 2025-09-22 4 A 0 600000 0 A 2035-09-22 Common Shares 600000 600000 D 25% of the shares subject to this option shall vest on September 1, 2026, and the balance shall vest ratably over 36 months /s/ Max A. Milbury, Attorney in Fact for Neil Warma 2025-09-24