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Stock-based Compensation - Additional Information (Detail) - USD ($)
1 Months Ended 12 Months Ended
Jan. 17, 2017
Jan. 31, 2016
Jan. 31, 2015
Jan. 31, 2014
Feb. 28, 2013
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Total intrinsic value of options exercised           $ 300,000 $ 27,000,000 $ 8,100,000
Unrecognized stock-based compensation cost related to the unvested stock option           $ 18,400,000    
Weighted-average period to recognize compensation cost unvested stock option           2 years 3 months 18 days    
Weighted average fair value of options granted           $ 7.53 $ 22.78 $ 7.54
Stock-based compensation expense (reversal)           $ 13,145,000 $ 11,616,000 $ 5,230,000
Options granted to purchase of common stock           1,343,825    
Dividend rate           0.00% 0.00% 0.00%
Non Employee Stock Option [Member]                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Stock-based compensation expense               $ 1,200,000
Stock option canceled to non-employee           25,000 75,000  
Stock-based compensation expense (reversal)           $ (12,000) $ (1,000,000)  
Options granted to purchase of common stock           0 0 110,000
Weighted-average exercise price of options granted to non-employee               $ 12.56
Risk-free interest rate           1.22% 2.17%  
Dividend rate           0.00% 0.00%  
Expected volatility           88.83% 86.02%  
Expected term           8 years 8 years 7 months 6 days  
Stock Compensation Plan Agreements [Member]                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Option vesting period           4 years    
Share based compensation, contractual life           10 years    
Stock Options and Restricted Stock Units [Member]                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Stock-based compensation expense           $ 13,200,000 $ 12,600,000 $ 4,000,000
Restricted Stock Units [Member]                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Unrecognized stock-based compensation cost related to the unvested stock option           $ 1,200,000    
Weighted-average period of cost expected to be recognized           2 years    
Stock Incentive Plan 2013 [Member]                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Shares authorized for issuance under stock incentive plan         1,688,777      
Outstanding shares available for future grants           1,354,464    
Increase in number of shares of common stock issuable   1,463,391 1,232,232 1,025,171        
Stock Incentive Plan 2013 [Member] | Subsequent Events [Member]                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Increase in number of shares of common stock issuable 1,477,677              
Stock Incentive Plan 2006 [Member]                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Outstanding shares available for future grants         258,265      
Maximum threshold of shares outstanding for determining availability of grants         3,000,000      
Percentage threshold of shares outstanding for determining availability of grants         4.00%