X0306 4 2015-05-15 0 0001373707 TETRAPHASE PHARMACEUTICALS INC TTPH 0001509643 THOMPSON JOHN CRAIG 480 ARSENAL ST SUITE 110 WATERTOWN MA 02472 0 1 0 0 Chief Operating Officer Common Stock 2015-05-15 4 M 0 30000 14.45 A 30343 D Common Stock 2015-05-15 4 S 0 30000 39.63 D 343 D Employee Stock Option (right to buy) 14.45 2015-05-15 4 M 0 30000 0.00 D 2024-02-02 Common Stock 30000 220000 D The exercise and sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2015. The amount of securities beneficially owned by the reporting person following the transaction reported on this Form 4 reflects the purchase by the reporting person of 172 shares of common stock on November 17, 2014 and 171 shares of common stock on May 14, 2015. Both of these purchases were done under the issuer's 2014 Employee Stock Purchase Plan ("ESPP"). The shares purchased in November 2014 under the ESPP were inadvertently omitted from the amount of securities beneficially owned that were reported on the Form 4 filed by the reporting person on January 9, 2015. The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $39.14 to $40.08 per share. The reporting person herby undertakes, upon request of the staff of the U.S. Securities and Exchange Commission, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This option vested as to 20% of the shares on February 3, 2014 and another 20% on February 3, 2015 and further vests as to 5% of the shares at the end of each successive three-month period thereafter until February 3, 2018. /s/Maria Stahl as Attorney-in-Fact for John Craig Thomspon 2015-05-19