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    <periodOfReport>2020-07-28</periodOfReport>

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    <issuer>
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        <issuerName>TETRAPHASE PHARMACEUTICALS INC</issuerName>
        <issuerTradingSymbol>TTPH</issuerTradingSymbol>
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            <rptOwnerName>Stahl Maria D</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TETRAPHASE PHARMACEUTICALS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>480 ARSENAL WAY</rptOwnerStreet2>
            <rptOwnerCity>WATERTOWN</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02472</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <officerTitle>See Remarks</officerTitle>
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    <footnotes>
        <footnote id="F1">Pursuant to the terms of that certain Agreement and Plan of Merger, dated as of June 24, 2020, by and among Tetraphase Pharmaceuticals, Inc. (&quot;Tetraphase&quot;), TTP Merger Sub, Inc. and La Jolla Pharmaceutical Company (the &quot;Merger Agreement&quot;), these shares were tendered and disposed of at the Acceptance Time (all terms capitalized but not defined shall have the meaning given to them in the Merger Agreement) in exchange for the right to receive (i) $2.00 per Share (the &quot;Cash Consideration&quot;), to the holder in cash, without interest and less any applicable withholding taxes, plus (ii) one non-transferable contractual contingent value right per Share (a &quot;CVR&quot;) representing the right to receive certain consideration based on the achievement of net sales milestones.</footnote>
        <footnote id="F2">Each restricted stock unit (&quot;Tetraphase RSU&quot;) represents a right to vest in and receive shares of Tetraphase common stock and each performed-vested restricted stock unit (&quot;Tetraphase PRSU&quot;) represents a right to vest in and receive shares of Tetraphase common stock only if specific regulatory and commercial milestones are achieved.</footnote>
        <footnote id="F3">Pursuant to the Merger Agreement, as of immediately prior to the Effective Time, each outstanding Tetraphase RSU and each outstanding Tetraphase PRSU will vest in full and automatically be canceled and converted into the right to receive, subject to applicable withholding, the product of (a) the total number of Shares then underlying such Tetraphase RSU or Tetraphase PRSU, as applicable, multiplied by (b) the Offer Price, without any interest.</footnote>
    </footnotes>

    <remarks>Chief Business Officer and General Counsel</remarks>

    <ownerSignature>
        <signatureName>/s/ Maria Stahl</signatureName>
        <signatureDate>2020-07-29</signatureDate>
    </ownerSignature>
</ownershipDocument>
