<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3/A</documentType>

    <periodOfReport>2007-02-21</periodOfReport>

    <dateOfOriginalSubmission>2007-02-21</dateOfOriginalSubmission>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001373641</issuerCik>
        <issuerName>Highland Distressed Opportunities, Inc.</issuerName>
        <issuerTradingSymbol>HCD</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001365143</rptOwnerCik>
            <rptOwnerName>Daugherty Pat H</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>13455 NOEL ROAD, SUITE 800</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>DALLAS</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>75240</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>PORTFOLIO MANAGER</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <remarks>This amendment restates the original filing in its entirety.</remarks>

    <ownerSignature>
        <signatureName>PATRICK H. DAUGHERTY</signatureName>
        <signatureDate>2007-02-26</signatureDate>
    </ownerSignature>
</ownershipDocument>
