Income Taxes - Schedule of Effective Income Tax Rate - Post Adoption (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Amount
U.S. Federal Statutory Tax Rate	$ (14,248)	$ (11,606)
State and Local Income Tax, Net of Federal (National) Income Tax Effect	0	(3,265)
Foreign Tax Effects	381	1,242
Effect of Changes in Tax Laws or Rates Enacted in the Current Period	0	1,346
Effect of Cross-Border Tax Laws	0
Tax Credits
Research & Development Tax Credits	(822)
Orphan Drug Credits	(1,649)
Changes in valuation allowances	14,355	7,203
Nontaxable or Nondeductible Items
Stock-Based Compensation	1,685
Others	345
Changes in Unrecognized Tax Benefits	0
Other Adjustments	(47)	(163)
Effective tax rate	$ 0	$ 0
Percent
U.S. Federal Statutory Tax Rate	21.00%	21.00%
State and Local Income Tax, Net of Federal (National) Income Tax Effect	0.00%	5.90%
Foreign Tax Effects	(0.60%)	(2.20%)
Effect of Changes in Tax Laws or Rates Enacted in the Current Period	0.00%	(2.40%)
Effect of Cross-Border Tax Laws	0.00%
Tax Credits
Research & Development Tax Credits	1.20%
Orphan Drug Credits	2.40%
Changes in valuation allowances	(21.20%)	(13.00%)
Nontaxable or Nondeductible Items
Stock-Based Compensation	(2.50%)
Others	(0.50%)
Changes in Unrecognized Tax Benefits	0.00%
Other Adjustments	0.20%	0.30%
Effective tax rate	0.00%	0.00%