Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of Company's losses before income taxes and provision (benefit) for income taxes

The Company's losses before income taxes and provision (benefit) for income taxes is as follows (in thousands):

	Year ended December 31,
	2022		2021
Loss before income taxes	$	(81,351)	$	(58,417)
Provision (benefit) for income taxes	—		(52)

Schedule of Effective Income Tax Rate Reconciliation

A reconciliation of the federal statutory income tax rate to the Company's effective income tax rate is as follows:

	Year ended December 31,
	2022		2021
Expected provision at statutory rate	21.0	%	21.0	%
State income tax, net of federal benefit	7.4	%	7.9	%
Tax credits	3.3	%	3.2	%
Change in state tax rate	(11.6)	%	—	%
Other, net	(1.7)	%	(0.1)	%
Change in valuation allowance	(18.4)	%	(31.9)	%
Effective tax rate	—	%	0.1	%

Schedule of Deferred Tax Assets

The Company's deferred tax assets (liabilities) are comprised of the following (in thousands):

	As of December 31,
	2022		2021
Deferred tax assets:
Net operating loss carryforwards	$	51,884	$	52,038
Capital loss carryforwards	7,298		7,298
Start-up costs	9,699		11,235
Accruals and reserves	629		448
Intellectual property	5,057		1,960
Stock-based compensation	2,709		2,064
Capitalization of research and development expense	10,379		—
Tax credits	6,655		4,350
Lease liabilities	1,029		461
Total deferred tax assets	95,339		79,854
Valuation allowance	(94,364)		(79,395)
Deferred tax assets, net of valuation allowance	$	975	$	459
Deferred tax liabilities:
Lease right-of-use assets	(975)		(459)
Net deferred tax assets	$	—	$	—

Schedule of Income Tax Contingencies

A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows (in thousands):

	Year ended December 31,
	2022		2021
Gross unrecognized tax benefits at beginning of year	$	303	$	303
Additions for tax positions taken in a prior year	—		—
Additions for tax positions taken in the current year	—		—
Reductions for tax positions taken in the prior year due to settlement	—		—
Reductions for tax positions taken in the prior year due to statutes lapsing	—		—
Gross unrecognized tax benefits at end of year	$	303	$	303