XML 70 R41.htm IDEA: XBRL DOCUMENT v3.20.4
License and Development Agreements (Details) - USD ($)
1 Months Ended 12 Months Ended
Sep. 27, 2019
Jan. 31, 2017
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2017
License agreements:          
Collaboration revenue     $ 42,620 $ 0  
Collaborative Agreement | Advaite, Inc.          
License agreements:          
Reduction of research and development expense     300,000    
Collaboration revenue     42,620    
Collaboration Agreement with CanSino Biologics          
License agreements:          
Term (in years) 10 years        
Period within with CanSino to provide development cost statement 45 days        
Period within which to reimburse CanSino of development costs 1 year        
Schepens Eye Research Institute          
License agreements:          
Cancellation period, notice         180 days
License maintenance fee, year one         $ 25,000
License maintenance fee, year two         25,000
License maintenance fee, thereafter         100,000
Potential development and regulatory milestone payments         6,000,000.0
Potential commercial milestone payment         $ 10,100,000
Milestone payment     0    
Royalty payments     $ 0    
Cancellation notice, payments period         30 days
Cancellation notice, breach cure period, bankruptcy         90 days
Schepens Eye Research Institute Research Agreement          
License agreements:          
Cancellation period, notice         60 days
Collaboration agreement with University of Colorado          
License agreements:          
Cancellation period, notice     60 days    
Potential development and regulatory milestone payments   $ 1,500,000      
Milestone payment     $ 0    
Royalty payments     $ 0    
Cancellation notice, payments period         60 days
Minimum annual royalty payment         $ 20,000