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Stock-Based Compensation - Summary of Stock Option Activity Under the 2012 and 2013 Plans (Detail) - USD ($)
$ / shares in Units, $ in Thousands
9 Months Ended 12 Months Ended
Sep. 30, 2018
Dec. 31, 2017
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]    
Number of Options, Outstanding Beginning Balance 2,158,348  
Number of Options, Granted 1,530,150  
Number of Options, Exercised (919)  
Number of Options, Cancelled (32,001)  
Number of Options, Outstanding Ending Balance 3,655,578 2,158,348
Number of Options, Vested and expected to vest outstanding 3,288,917  
Number of Options, Exercisable 1,460,898  
Weighted Average Exercise Price, Outstanding Beginning Balance $ 4.40  
Weighted Average Exercise Price, Granted 2.38  
Weighted Average Exercise Price, Exercised 2.56  
Weighted Average Exercise Price, Cancelled 2.71  
Weighted Average Exercise Price, Outstanding Ending Balance 3.57 $ 4.40
Weighted Average Exercise Price, Vested and expected to vest outstanding 3.69  
Weighted Average Exercise Price, Exercisable $ 4.86  
Weighted Average Remaining Contractual Term, Outstanding 8 years 3 months 18 days 8 years 1 month 6 days
Weighted Average Remaining Contractual Term, Vested and expected to vest outstanding 8 years 2 months 12 days  
Weighted Average Remaining Contractual Term, Exercisable 7 years 2 months 12 days  
Aggregate Intrinsic Value, Outstanding   $ 436