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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001967115</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001371285</issuerCik>
      <issuerName>TRUPANION, INC.</issuerName>
      <secFileNumber>001-36537</secFileNumber>
      <issuerAddress>
        <com:street1>6100 4TH AVENUE SOUTH</com:street1>
        <com:street2>SUITE 200</com:street2>
        <com:city>SEATTLE</com:city>
        <com:stateOrCountry>WA</com:stateOrCountry>
        <com:zipCode>98108</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>888-733-2685</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>WORRA TRAVIS</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>MORGAN STANLEY SMITH BARNEY LLC EXECUTIVE SERVICES</name>
        <address>
          <com:street1>200 W CIVIC DR. - 4TH FLOOR</com:street1>
          <com:city>SANDY</com:city>
          <com:stateOrCountry>UT</com:stateOrCountry>
          <com:zipCode>84070</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2000</noOfUnitsSold>
      <aggregateMarketValue>109120.00</aggregateMarketValue>
      <noOfUnitsOutstanding>42200000</noOfUnitsOutstanding>
      <approxSaleDate>11/04/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>11/25/2020</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>22</amountOfSecuritiesAcquired>
      <paymentDate>11/25/2020</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>02/22/2021</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>51</amountOfSecuritiesAcquired>
      <paymentDate>02/22/2021</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>02/25/2021</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>331</amountOfSecuritiesAcquired>
      <paymentDate>02/25/2021</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>05/25/2021</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>106</amountOfSecuritiesAcquired>
      <paymentDate>05/25/2021</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>08/25/2021</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>106</amountOfSecuritiesAcquired>
      <paymentDate>08/25/2021</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>11/25/2021</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>108</amountOfSecuritiesAcquired>
      <paymentDate>11/25/2021</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>02/25/2022</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>274</amountOfSecuritiesAcquired>
      <paymentDate>02/25/2022</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>05/25/2022</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>135</amountOfSecuritiesAcquired>
      <paymentDate>05/25/2022</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>08/25/2022</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>138</amountOfSecuritiesAcquired>
      <paymentDate>08/25/2022</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>11/25/2022</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>327</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>327</amountOfSecuritiesAcquired>
      <paymentDate>11/25/2022</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>02/25/2023</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>402</amountOfSecuritiesAcquired>
      <paymentDate>02/25/2023</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>11/04/2024</noticeDate>
      <signature>/s/ Travis Paul Worra</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
