<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
	<headerData>
        <submissionType>144</submissionType>
                <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001276840</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
        <liveTestFlag>LIVE</liveTestFlag>




                </filerInfo>
    </headerData>

     <formData>
        <issuerInfo>
            <issuerCik>0001370053</issuerCik>
			<issuerName>ANAPTYSBIO, INC</issuerName>


			    <secFileNumber>001-37985</secFileNumber>


			<issuerAddress>
				<com:street1>10770 WATERIDGE CIRCLE, SUITE 210</com:street1>
                				<com:city>SAN DIEGO</com:city>
				<com:stateOrCountry>CA</com:stateOrCountry>
				<com:zipCode>94005</com:zipCode>
			</issuerAddress>

			<issuerContactPhone>858-362-6295</issuerContactPhone>
			<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>DENNIS MULROY</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>

			<relationshipsToIssuer>

				    <relationshipToIssuer>Officer</relationshipToIssuer>

			</relationshipsToIssuer>
		</issuerInfo>

				          <securitiesInformation>
			<securitiesClassTitle>Common Stock</securitiesClassTitle>
			<brokerOrMarketmakerDetails>
				<name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
				<address>
				<com:street1>1 New York Plaza</com:street1>
                				<com:street2>8th Floor</com:street2>
                				<com:city>New York</com:city>
				<com:stateOrCountry>NY</com:stateOrCountry>
				<com:zipCode>10004</com:zipCode>
				</address>
			</brokerOrMarketmakerDetails>
			<noOfUnitsSold>2515</noOfUnitsSold>
			<aggregateMarketValue>113703.15</aggregateMarketValue>
			<noOfUnitsOutstanding>27688470</noOfUnitsOutstanding>
			<approxSaleDate>01/08/2026</approxSaleDate>
			<securitiesExchangeName>NASDAQ</securitiesExchangeName>
		</securitiesInformation>

    		       <securitiesToBeSold>
         <securitiesClassTitle>Common </securitiesClassTitle>
         <acquiredDate>01/08/2026</acquiredDate>
         <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>2515</amountOfSecuritiesAcquired>
                  <paymentDate>01/08/2026</paymentDate>
                  <natureOfPayment>Cash</natureOfPayment>
      </securitiesToBeSold>

    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>


     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>Dennis Mulroy</name>
            <address>
               <com:street1>10770 Wateridge Circle, Suite 210</com:street1>
                              <com:city>San Diego</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>92121</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common</securitiesClassTitle>
         <saleDate>01/07/2026</saleDate>
         <amountOfSecuritiesSold>1908</amountOfSecuritiesSold>
         <grossProceeds>83780.28</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>Dennis Mulroy</name>
            <address>
               <com:street1>10770 Wateridge Circle, Suite 210</com:street1>
                              <com:city>San Diego</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>92121</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common</securitiesClassTitle>
         <saleDate>01/05/2026</saleDate>
         <amountOfSecuritiesSold>3363</amountOfSecuritiesSold>
         <grossProceeds>1511166.85</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>Dennis Mulroy</name>
            <address>
               <com:street1>10770 Wateridge Circle, Suite 210</com:street1>
                              <com:city>San Diego</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>92121</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common</securitiesClassTitle>
         <saleDate>12/22/2025</saleDate>
         <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
         <grossProceeds>500000</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>Dennis Mulroy</name>
            <address>
               <com:street1>10770 Wateridge Circle, Suite 210</com:street1>
                              <com:city>San Diego</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>92121</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common</securitiesClassTitle>
         <saleDate>12/16/2025</saleDate>
         <amountOfSecuritiesSold>15725</amountOfSecuritiesSold>
         <grossProceeds>705333.1</grossProceeds>
      </securitiesSoldInPast3Months>


        <noticeSignature>
            <noticeDate>01/09/2026</noticeDate>
                        <signature> /s/ Dennis Mulroy</signature>
        </noticeSignature>
	</formData>
    </edgarSubmission>
