X0407 4 2023-04-03 0 0001370053 ANAPTYSBIO, INC ANAB 0001707797 Jain Rita C/O ANAPTYSBIO, INC. 10770 WATERIDGE CIRCLE, SUITE 210 SAN DIEGO CA 92121 1 0 0 0 0 Stock Option (right to buy) 22.09 2023-04-03 4 A 0 10600 0.00 A 2033-04-02 Common Stock 10600 10600 D Stock Option (right to buy) 22.09 2023-04-03 4 A 0 8015 0.00 A 2033-04-02 Common Stock 8015 8015 D Restricted Stock Unit 2023-04-03 4 A 0 3900 0.00 A Common Stock 3900 3900 D Restricted Stock Unit 2023-04-03 4 A 0 3234 0.00 A Common Stock 3234 3234 D The stock option vests as of 1/36 of the total shares monthly beginning on May 6, 2023 until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The stock option vests as of 1/9 of the total shares monthly beginning on May 6, 2023 and each month thereafter until fully vested on January 6, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date. Each restricted stock unit ("RSU") represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration. The RSUs shall vest as to 1/3 of the total shares on June 15, 2024, and thereafter vests as to 1/3 of the total RSUs on June 15, 2025; and as to 1/3 of the total RSUs on June 15, 2026, subject to the provision of services to the Company on each vesting date. The RSUs vests as to 100% of the total RSUs on the date of the Issuer's 2024 annual meeting of shareholders, subject to the Reporting Person's provision of service to the Issuer on each vesting date. /s/ Eric Loumeau, Attorney-in-Fact 2023-04-06