X0306 4 2022-09-14 0 0001370053 ANAPTYSBIO, INC ANAB 0001239648 LOUMEAU ERIC J C/O ANAPTYSBIO, INC. 10770 WATERIDGE CIRCLE, SUITE 210 SAN DIEGO CA 92121 0 1 0 0 COO, General Counsel Restricted Stock Unit 2022-09-14 4 A 0 12000 0.00 A Common Stock 12000 12000 D Represents a one-time retention grant of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive 1 share of the Issuer's Common Stock upon settlement for no consideration. 50% of the total RSUs vest on September 14, 2023 and September 14, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date. In addition to the remaining options to purchase 12,000 shares of common stock as set forth in Table II above, the Reporting Person also holds an additional options to purchase up to an aggregate of 308,000 shares of common stock, which options vest according to their terms. /s/ Eric Loumeau 2022-09-16