X0306 4 2022-06-23 0 0001370053 ANAPTYSBIO, INC ANAB 0001239648 LOUMEAU ERIC J C/O ANAPTYSBIO, INC. 10770 WATERIDGE CIRCLE, SUITE 210 SAN DIEGO CA 92121 0 1 0 0 COO, General Counsel Stock Option (right to buy) 29.70 2022-06-23 4 A 0 10000 0.00 A 2022-06-23 2031-02-09 Common Stock 10000 10000 D On February 10, 2021, the reporting person was granted a performance-based option to purchase 10,000 shares of the Issuer's common stock, subject to the achievement of certain corporate performance criteria and the reporting person's continued service to the Issuer upon achievement thereof. The performance criteria were achieved on the date in Column 3, resulting in the vesting of the entire award. In addition to the remaining options to purchase 10,000 shares of common stock as set forth in Table II above, the Reporting Person also holds (i) additional options to purchase up to an aggregate of 298,000 shares of common stock, which options vest according to their terms, and (ii) 523 shares of common stock held directly. /s/ Eric Loumeau 2022-06-27