X0306 4 2017-01-31 0 0001370053 ANAPTYSBIO INC ANAB 0001341382 Topper James N C/O FRAZIER HEALTHCARE PARTNERS 601 UNION STREET, SUITE 3200 SEATTLE WA 98101 1 0 1 0 Common Stock 2017-01-31 4 C 0 2228377 0.00 A 2228377 I see footnote Common Stock 2017-01-31 4 C 0 733740 0.00 A 733740 I see footnote Common Stock 2017-01-31 4 C 0 209095 0.00 A 209095 I see footnote Common Stock 2017-01-31 4 P 0 311291 15.00 A 1045031 I see footnote Common Stock 2017-01-31 4 P 0 88709 15.00 A 297804 I see footnote Series B Preferred Stock 0.00 2017-01-31 4 C 0 1428571 0.00 D Common Stock 1428571 0 I see footnote Series C Preferred Stock 0.00 2017-01-31 4 C 0 604055 0.00 D Common Stock 604055 0 I see footnote Series C-1 Preferred Stock 0.00 2017-01-31 4 C 0 195751 0.00 D Common Stock 195751 0 I see footnote Series D Preferred Stock 0.00 2017-01-31 4 C 0 733740 0.00 D Common Stock 733740 0 I see footnote Series D Preferred Stock 0.00 2017-01-31 4 C 0 209095 0.00 D Common Stock 209095 0 I see footnote In connection with the consummation of the Issuer's initial public offering on January 31, 2017, each share of Series B Preferred Stock, Series C Preferred Stock, Series C-1 Preferred Stock and Series D Preferred Stock automatically converted into one (1) share of Common Stock for no additional consideration, and had no expiration date. All shares of Common Stock issued upon conversion were aggregated. Represents shares held by Frazier Healthcare V, L.P., an affiliate of Frazier Healthcare Ventures. Dr. Topper is a General Partner of Frazier Healthcare. Mr. Topper disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. Represents shares held by Frazier Healthcare VII, L.P., an affiliate of Frazier Healthcare Ventures. Dr. Topper is a General Partner of Frazier Healthcare. Mr. Topper disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. Represents shares held by Frazier Healthcare VII-A, L.P., an affiliate of Frazier Healthcare Ventures. Dr. Topper is a General Partner of Frazier Healthcare. Mr. Topper disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. /s/ James N. Topper by Dominic Piscitelli, Attorney-in-Fact 2017-01-31