X0202 SCHEDULE 13G/A 0000919574-26-003215 0002115022 XXXXXXXX LIVE 1 Common Stock, par value $0.001 per share 06/30/2026 0001370053 ANAPTYSBIO, INC 032724106 10770 WATERIDGE CIRCLE, SUITE 210 SAN DIEGO CA 92121 Rule 13d-1(b) Sirenia Capital Management LP b DE 0.00 1491959.00 0.00 1491959.00 1491959.00 N 5.0 IA PN Alex Silverstein b X1 0.00 1491959.00 0.00 1491959.00 1491959.00 N 5.0 HC IN ANAPTYSBIO, INC 10770 Wateridge Circle, Suite 210, San Diego, CA 92121 This statement is filed by: (i) Sirenia Capital Management LP ("Sirenia") with respect to the common stock, par value $0.001 per share ("Common Stock"), of AnaptysBio, Inc. (the "Issuer") held by a managed account it manages (the "Sirenia Account"); and (ii) Alex Silverstein ("Mr. Silverstein"), the managing member of Sirenia Capital Management GP LLC, the general partner of Sirenia, with respect to the Common Stock held by the Sirenia Account. The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Securities Exchange Act of 1934, the beneficial owner of the securities reported herein. The address of the principal business office of Sirenia and Mr. Silverstein is 1674 Meridian Avenue, Suite 320, Miami Beach, FL 33139. Sirenia is a Delaware limited partnership. Mr. Silverstein is a United States citizen. N IA HC The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The percentage set forth in this Schedule 13G is calculated based upon an aggregate of 29,608,481 shares of Common Stock outstanding as of June 22, 2026, as reported in the Issuer's Definitive Proxy Statement on Schedule 14A filed with the Securities and Exchange Commission on June 29, 2026. 5.0% The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Y N See Item 2(a). The Sirenia Account, which is an account of Point72 Associates II, LLC, has the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, more than 5 percent of the outstanding Common Stock. N See Item 2(a) and Item 3. Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Sirenia Capital Management LP /s/ Kolby Loft 08/14/2026 Alex Silverstein /s/ Alex Silverstein 08/14/2026