X0306 4 2022-05-20 0 0001369568 CATALYST PHARMACEUTICALS, INC. CPRX 0001292636 Tierney David S 355 ALHAMBRA CIRCLE, SUITE 801 CORAL GABLES FL 33134 1 0 0 0 Common stock, par value $0.001 per share 2022-05-20 4 M 0 20000 2.53 A 328207 D Common stock, par value $0.001 per share 2022-05-20 4 S 0 20000 D 308207 D Options to purchase common stock 2.53 2022-05-20 4 M 0 20000 0 D 2022-12-30 Common Stock 20000 252333 D Dr. Tierney has advised the Company that the sale of shares was to pay the exercise cost of the shares and to raise funds for personal reasons and does not relate to any disagreements with the Company on any matter relating to the Company's operations, policies or practices. Dr. Tierney remains a Director of the Company. 12,803 shares were sold at a price of $7.03 per share, 5,626 were sold at a price of $7.04 per share, and 1,571 were sold at a price of $7.05 per share. The option was granted on December 30, 2015 and previously vested in two annual installments. /s/ David S. Tierney 2022-05-24