<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0609</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2026-04-28</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0001831840</issuerCik>
        <issuerName>SEMrush Holdings, Inc.</issuerName>
        <issuerTradingSymbol>SEMR</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001369322</rptOwnerCik>
            <rptOwnerName>Wagner William Raymond</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>false</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>C/O SEMRUSH HOLDINGS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>800 BOYLSTON STREET, SUITE 2475</rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02199</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Executive Officer</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Class A Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2026-04-28</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>D</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness></transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>1630097</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>12.00</value>
                    <footnoteId id="F3"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">A portion of these shares represent restricted stock units (&quot;RSUs&quot;) and restricted stock. Each restricted stock and RSU represents a right to receive one share of the Issuer's common stock (&quot;Common Stock&quot;) upon vesting.</footnote>
        <footnote id="F2">On April 28, 2026, pursuant to the terms of that certain Agreement and Plan of Merger (the &quot;Merger Agreement&quot;), dated as of November 18, 2025, by and among Semrush Holdings, Inc., a Delaware corporation (the &quot;Issuer&quot;), Adobe Inc., a Delaware corporation (&quot;Parent&quot;), and Fenway Merger Sub, Inc., a Delaware corporation and a direct, wholly owned subsidiary of Parent (&quot;Merger Sub&quot;), Merger Sub merged with and into the Issuer (the &quot;Merger&quot;), with the Issuer surviving the Merger as a wholly owned subsidiary of Parent.</footnote>
        <footnote id="F3">At the effective time of the Merger (the &quot;Effective Time&quot;), each share of Common Stock held by the reporting person was converted into the right to receive $12.00 in cash (the &quot;Merger Consideration&quot;).</footnote>
        <footnote id="F4">At the Effective Time, each RSU award that was subject solely to service-based vesting requirements (&quot;RSU Award&quot;) held by a non-employee director, contractors or other certain service providers (each, a &quot;Specified Individual&quot;) was cancelled and cashed out for a payment equal to the Merger Consideration in respect of each underlying share and each other RSU award was converted into a restricted stock unit award relating to Parent common stock (an &quot;Adobe RSU Award&quot;) in respect of a number of shares of Parent common stock obtained by multiplying the number of shares of Common Stock underlying the RSU Award by the quotient of (a) the Merger Consideration divided by (b) the closing price per share of Adobe common stock over the 30 consecutive calendar days ending on (and including) the second to last calendar day preceding the closing date (the &quot;Adobe Trading Price&quot;, and such quotient, the &quot;Equity Award Conversion Ratio&quot;).</footnote>
        <footnote id="F5">At the Effective Time, each restricted stock award was converted into a restricted stock award of Parent in respect of a number of shares of Parent common stock obtained by multiplying the number of shares of Common Stock underlying the restricted stock award by the Equity Award Conversion Ratio.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ David Mason, attorney-in-fact</signatureName>
        <signatureDate>2026-04-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
