<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001369032</cik>
        <entityName>FrontPoint Onshore Healthcare Flagship Enhanced Fund, L.P.</entityName>
        <issuerAddress>
            <street1>TWO GREEWICH PLAZA</street1>
            <city>GREENWICH</city>
            <stateOrCountry>CT</stateOrCountry>
            <zipCode>06830</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>203-622-5200</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>FrontPoint Onshore Healthcare Fund 2X, L.P.</previousName>
            <previousName>FrontPoint Onshore Healthcare Fund, L.P.</previousName>
            <previousName>FrontPoint Healthcare Fund 2X, L.P.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>FRONTPOINT ONSHORE HEALTHCARE FUND 2X LP</previousName>
        </edgarPreviousNameList>
        <entityType>Limited Partnership</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2005</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>-</firstName>
                <lastName>FPP Healthcare Flagship Enhanced Fund GP, LLC</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Two Greenwich Plaza</street1>
                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <zipCode>06830</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>General Partner of the Issuer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>-</firstName>
                <lastName>FrontPoint Partners LLC</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Two Greenwich Plaza</street1>
                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <zipCode>06830</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <lastName>Webb</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Two Greenwich Plaza</street1>
                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <zipCode>06830</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>T.A.</firstName>
                <lastName>McKinney</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Two Greenwich Plaza</street1>
                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <zipCode>06830</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Geraldine</firstName>
                <lastName>Boyle</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Two Greenwich Plaza</street1>
                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <zipCode>06830</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <lastName>Jacoby</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Two Greenwich Plaza</street1>
                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <zipCode>06830</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Eric</firstName>
                <lastName>Mendelsohn</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Two Greenwich Plaza</street1>
                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <zipCode>06830</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michele</firstName>
                <lastName>Eng</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Two Greenwich Plaza</street1>
                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <zipCode>06830</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Joseph</firstName>
                <middleName>Frank</middleName>
                <lastName>Skowron III</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Two Greenwich Plaza</street1>
                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <zipCode>06830</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jason</firstName>
                <lastName>Bonadio</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Two Greenwich Plaza</street1>
                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <zipCode>06830</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ajay</firstName>
                <lastName>Bhalla</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Two Greenwich Plaza</street1>
                <city>Greenwich</city>
                <stateOrCountry>CT</stateOrCountry>
                <zipCode>06830</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pooled Investment Fund</industryGroupType>
            <investmentFundInfo>
                <investmentFundType>Hedge Fund</investmentFundType>
                <is40Act>false</is40Act>
            </investmentFundInfo>
        </industryGroup>
        <issuerSize>
            <aggregateNetAssetValueRange>Decline to Disclose</aggregateNetAssetValueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>3C</item>
            <item>3C.7</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>9999999997-06-030215</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2006-06-05</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isPooledInvestmentFundType>true</isPooledInvestmentFundType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>100000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Citigroup Global Markets Inc.</recipientName>
                <recipientCRDNumber>7059</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>390-388 Greenwich Street</street1>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10013</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citigroup Global Markets Limited</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>Citigroup Centre</street1>
                    <street2>33 Canada Square Canary Wharf</street2>
                    <city>London</city>
                    <stateOrCountry>X0</stateOrCountry>
                    <zipCode>E14 5LB</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citigroup Global Markets Asia Limited</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>50/F, Citibank Plaza</street1>
                    <street2>3 Garden Road, Central</street2>
                    <city>-</city>
                    <stateOrCountry>K3</stateOrCountry>
                    <zipCode>-</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citigroup Global Markets Singapore Pte Limited</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>1 Temasek Avenue</street1>
                    <street2>#39-02 Millenia Tower</street2>
                    <city>-</city>
                    <stateOrCountry>U0</stateOrCountry>
                    <zipCode>039192</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citibank, N.A., New York Branch</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>399 Park Avenue</street1>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10043</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citibank, N.A., London Branch</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>Citigroup Centre</street1>
                    <street2>25 Canada Square, Canary Wharf</street2>
                    <city>London</city>
                    <stateOrCountry>X0</stateOrCountry>
                    <zipCode>E14 5LB</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citibank, N.A., Zurich Branch</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>Seestrasse 25</street1>
                    <street2>P.O. Box 3760</street2>
                    <city>8021 Zurich</city>
                    <stateOrCountry>V8</stateOrCountry>
                    <zipCode>-</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citibank, N.A., Geneva Branch</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>16, Quai General-Guisan</street1>
                    <street2>P.O. Box 3946</street2>
                    <city>Geneva 3</city>
                    <stateOrCountry>V8</stateOrCountry>
                    <zipCode>CH-1211</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citibank, N.A., Singapore Branch</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>1 Temasek Avenue</street1>
                    <street2>#09-00 Millenia Tower</street2>
                    <city>-</city>
                    <stateOrCountry>U0</stateOrCountry>
                    <zipCode>039192</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citibank, N.A., Hong Kong Branch</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>40/F, Citibank Tower</street1>
                    <street2>3 Garden Road</street2>
                    <city>-</city>
                    <stateOrCountry>K3</stateOrCountry>
                    <zipCode>-</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citibank, N.A., Jersey, Channel Islands Branch</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>P.O. Box 561</street1>
                    <street2>38 Esplanade</street2>
                    <city>St Helier, Jersey</city>
                    <stateOrCountry>Y9</stateOrCountry>
                    <zipCode>JE4 5WQ</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citibank International plc</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>33 Canada Square, Canary Wharf</street1>
                    <city>London</city>
                    <stateOrCountry>X0</stateOrCountry>
                    <zipCode>E14 5LB</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citibank (Switzerland)</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>Seestrasse 25</street1>
                    <street2>P.O. Box 3760</street2>
                    <city>8021 Zurich</city>
                    <stateOrCountry>V8</stateOrCountry>
                    <zipCode>-</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Citibank Canada Investment Funds Limited</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>123 Front Street West, Suite 1100</street1>
                    <city>Toronto</city>
                    <stateOrCountry>A6</stateOrCountry>
                    <zipCode>M5J 2M3</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Cititrust (Bahamas) Limited</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>P.O. Box N1576</street1>
                    <street2>Thompson Boulevard</street2>
                    <city>Nassau</city>
                    <stateOrCountry>C5</stateOrCountry>
                    <zipCode>-</zipCode>
                </recipientAddress>
                <statesOfSolicitationList></statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>Indefinite</totalOfferingAmount>
            <totalAmountSold>403750975</totalAmountSold>
            <totalRemaining>Indefinite</totalRemaining>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>39</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>Investors may pay a one-time upfront fee to brokers or dealers (&quot;Intermediaries&quot;), and the issuer's manager may pay an annual ongoing fee to certain Intermediaries. These fees are not expenses of the issuer and, therefore, not reflected herein.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>FrontPoint Onshore Healthcare Flagship Enhanced Fund, L.P.</issuerName>
                <signatureName>/s/ T.A. McKinney</signatureName>
                <nameOfSigner>T.A. McKinney</nameOfSigner>
                <signatureTitle>Authorized Signatory</signatureTitle>
                <signatureDate>2010-03-04</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
