<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001368993</cik>
        <entityName>WaferGen Bio-systems, Inc.</entityName>
        <issuerAddress>
            <street1>BAYSIDE TECHNOLOGY CENTER</street1>
            <street2>46531 FREMONT BLVD.</street2>
            <city>FREMONT</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>94538</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(510) 651-4450</issuerPhoneNumber>
        <jurisdictionOfInc>NEVADA</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>La Burbuja Cafe, Inc.</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2005</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alnoor</firstName>
                <lastName>Shivji</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o WaferGen Bio-systems, Inc.</street1>
                <street2>46531 Fremont Blvd.</street2>
                <city>Fremont</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94538</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Raymond</firstName>
                <middleName>Dean</middleName>
                <lastName>Hautamaki</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o WaferGen Bio-systems, Inc.</street1>
                <street2>46531 Fremont Blvd.</street2>
                <city>Fremont</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>94538</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1 - $1,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-11-11</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Units consisting of one share of common stock and one warrant to purchase 25% of one share of common stock.</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>25000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Gilford Securities Incorporated</recipientName>
                <recipientCRDNumber>8076</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>777 Third Avenue</street1>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10022</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CO</state>
                    <state>CT</state>
                    <state>FL</state>
                    <state>IN</state>
                    <state>MD</state>
                    <state>MA</state>
                    <state>MN</state>
                    <state>NY</state>
                    <state>NC</state>
                    <state>PA</state>
                    <state>RI</state>
                    <state>TX</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Spencer Trask Ventures, Inc.</recipientName>
                <recipientCRDNumber>28373</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>535 Madison Avenue</street1>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <zipCode>10016</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>FL</state>
                    <state>MI</state>
                    <state>NY</state>
                    <state>TX</state>
                    <state>WI</state>
                </statesOfSolicitationList>
            </recipient>
            <recipient>
                <recipientName>Newport Coast Securities, Inc.</recipientName>
                <recipientCRDNumber>16944</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>18872 MacArthur Blvd.</street1>
                    <street2>Suite 100</street2>
                    <city>Irvine</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <zipCode>92612</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>NJ</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>5085500</totalOfferingAmount>
            <totalAmountSold>5085500</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>37</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>381420</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>In addition to the dollar amount, sales commissions included warrants to purchase a total of 118,644 shares of stock at an exercise price of $2.50 per whole share.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>WaferGen Bio-systems, Inc.</issuerName>
                <signatureName>Hector Brush</signatureName>
                <nameOfSigner>Hector Brush</nameOfSigner>
                <signatureTitle>Principal Financial Officer</signatureTitle>
                <signatureDate>2010-02-23</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
