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7. STOCKHOLDERS' EQUITY (Tables)
3 Months Ended
Mar. 31, 2020
STOCKHOLDERS' EQUITY  
Schedule of assumptions
   Three Months Ended March 31,
   2020  2019
Expected term  5.8 - 6.3 years  5.8 - 6.3 years
Volatility   62%   61%
Dividend yield   0.0    0.0 
Risk-free interest rate   0.47-1.68%    2.25-2.63% 
Schedule of stock option activity
   Shares  Weighted Average Exercise Price
Balance at December 31, 2019   5,630,351   $4.76 
Forfeited   (29,087)  $3.65 
Expired   (4,852)  $4.60 
Granted   1,158,900   $2.96 
Exercised   (1,958)  $3.67 
Balance at March 31, 2020   6,753,354   $4.46 
           
Options exercisable   3,780,306   $5.29 
Stock-based compensation expense
   2020  2019
Research and development  $93,574   $86,523 
Plasma centers   7,244    11,540 
Selling, general and administrative   523,889    498,471 
Cost of product revenue   51,841    40,729 
Total stock-based compensation expense  $676,548   $637,263