X0306 4 2022-02-14 0 0001367920 CONCERT PHARMACEUTICALS, INC. CNCE 0001353528 Cassella James V C/O CONCERT PHARMACEUTICALS, INC. 65 HAYDEN AVENUE, SUITE 3000N LEXINGTON MA 02421 0 1 0 0 Chief Development Officer Common Stock 2022-02-14 4 S 0 3762 3.09 D 189822 D This sale was effected pursuant to a Rule 10b5-1 trading plan. These shares were sold to satisfy tax obligations associated with the vesting of restricted stock units. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $3.01 to $3.18, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the Staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within such range. /s/ Jeffrey A. Munsie, attorney-in-fact 2022-02-16