Consolidated Statements of Operations - USD ($) shares in Millions, $ in Millions	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenues:
Leases	$ 4.9
Total revenues	1,120.9	$ 1,792.7	$ 1,555.4
Operating expenses:
Cost of goods and services sold	693.7	757.5	524.0
Research and development	193.0	234.0	234.5
Selling, general and administrative	340.3	348.4	303.3
Goodwill impairment	6.7	41.7	0.0
Amortization of intangible assets	59.9	58.5	59.8
Total operating expenses	1,293.6	1,440.1	1,121.6
Income (loss) from operations	(172.7)	352.6	433.8
Other income (expense):
Interest expense	(37.3)	(34.5)	(31.3)
Other, net	(11.7)	(3.7)	4.7
Total other income (expense), net	(49.0)	(38.2)	(26.6)
Income (loss) before income taxes	(221.7)	314.4	407.2
Income tax provision	2.1	83.5	102.1
Net income (loss)	$ (223.8)	$ 230.9	$ 305.1
Net income (loss) per common share
Basic (in dollars per share)	$ (4.47)	$ 4.32	$ 5.79
Diluted (in dollars per share)	$ (4.47)	$ 4.27	$ 5.67
Shares used in computing net income (loss) per common share
Basic (in shares)	50.1	53.5	52.7
Diluted (in shares)	50.1	54.1	53.8
Product sales, net
Revenues:
Services	$ 966.2	$ 1,023.9	$ 989.8
Operating expenses:
Cost of goods and services sold	424.1	382.0	392.0
Total CDMO
Revenues:
Total CDMO	113.3	634.6	450.5
Operating expenses:
Cost of goods and services sold	269.6	375.5	132.0
Services
Revenues:
Services	108.4	334.9	166.7
Leases
Revenues:
Leases	4.9	299.7	283.8
Contracts and grants
Revenues:
Services	$ 41.4	$ 134.2	$ 115.1