Consolidated Statements of Operations - USD ($) shares in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues:
Total revenues	$ 1,792,700,000	$ 1,555,400,000	$ 1,106,000,000
Operating expenses:
Research and development	234,000,000.0	234,500,000	226,200,000
Selling, general and administrative	348,400,000	303,300,000	273,500,000
Goodwill impairment	41,700,000	0	0
Amortization of intangible assets	58,500,000	59,800,000	58,700,000
Total operating expenses	1,440,100,000	1,121,600,000	991,900,000
Income from operations	352,600,000	433,800,000	114,100,000
Other income (expense):
Interest expense	(34,500,000)	(31,300,000)	(38,400,000)
Other, net	(3,700,000)	4,700,000	1,700,000
Total other income (expense), net	(38,200,000)	(26,600,000)	(36,700,000)
Income before income taxes	314,400,000	407,200,000	77,400,000
Income taxes	83,500,000	102,100,000	22,900,000
Net income	$ 230,900,000	$ 305,100,000	$ 54,500,000
Net income per common share
Basic (in dollars per share)	$ 4.32	$ 5.79	$ 1.06
Diluted (in dollars per share)	$ 4.27	$ 5.67	$ 1.04
Shares used in computing net income per share
Basic (in shares)	53.5	52.7	51.5
Diluted (in shares)	54.1	53.8	52.4
Product sales, net
Revenues:
Services	$ 1,023,900,000	$ 989,800,000	$ 903,500,000
Operating expenses:
Cost of CDMO	382,000,000.0	392,000,000.0	372,300,000
Total CDMO
Revenues:
Total CDMO	634,600,000	450,500,000	80,000,000.0
Operating expenses:
Cost of CDMO	375,500,000	132,000,000.0	61,200,000
Services
Revenues:
Services	334,900,000	166,700,000	80,000,000.0
Leases
Revenues:
Leases	299,700,000	283,800,000	0
Contracts and grants
Revenues:
Services	$ 134,200,000	$ 115,100,000	$ 122,500,000