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Stockholders' equity, Stock options and restricted stock units (Details) - USD ($)
$ / shares in Units, $ in Millions
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Aggregate intrinsic value [Abstract]      
Weighted average period expected to be recognized related to unvested equity awards 2 years 2 months 12 days    
Compensation cost expected to be recognized related to unvested equity awards $ 32.8    
Employee Service Share-based Compensation, Aggregate [Abstract]      
Total stock-based compensation expense 23.2 $ 15.2 $ 18.5
Continuing Operations [Member]      
Employee Service Share-based Compensation, Aggregate [Abstract]      
Total stock-based compensation expense 23.2 15.2 17.4
Discontinued Operations [Member]      
Employee Service Share-based Compensation, Aggregate [Abstract]      
Total stock-based compensation expense $ 0.0 $ 0.0 $ 1.1
Stock Options [Member]      
Aggregate intrinsic value [Abstract]      
Weighted average remaining contractual term of options outstanding 4 years 4 years  
Weighted average remaining contractual term of options exercisable 3 years 3 years 2 months 12 days  
Weighted average grant date fair value of options granted (in dollars per share) $ 18.48 $ 10.53 $ 9.24
Total intrinsic value of options exercised $ 24.4 $ 13.9 $ 15.6
Total fair value of awards vested $ 16.9 $ 17.9 16.9
2006 Plan [Member] | Stock Options [Member]      
Options outstanding [Roll Forward]      
Outstanding, beginning of period (in shares) 2,121,405    
Stock options granted (in shares) 460,902    
Exercised (in shares) (665,183)    
Forfeited (in shares) (45,656)    
Outstanding, end of period (in shares) 1,871,468 2,121,405  
Exercisable, end of period (in shares) 1,081,513    
Options expected to vest, end of period (in shares) 696,083    
Weighted-Average Exercise Price [Roll Forward]      
Outstanding, beginning of period (in dollars per share) $ 25.48    
Stock options grant price (in dollars per share) 51.39    
Exercised (in dollars per share) 21.36    
Forfeited (in dollars per share) 33.14    
Outstanding, end of period (in dollars per share) 32.59 $ 25.48  
Exercisable, end of period (in dollars per share) 26.13    
Options expected to vest, end of period (in dollars per share) $ 41.10    
Aggregate Intrinsic Value [Abstract]      
Outstanding, beginning of period $ 44.5    
Outstanding, end of period 50.1 $ 44.5  
Exercisable, end of period 35.9    
Options expected to vest, end of period $ 12.8    
2006 Plan [Member] | Restricted Stock Units [Member]      
Restricted stock unit award activity [Roll Forward]      
Outstanding, beginning of period (in shares) 851,720    
Restricted stock units granted (in shares) 557,767    
Vested (in shares) (427,610)    
Forfeited (in shares) (60,784)    
Outstanding, end of period (in shares) 921,093 851,720  
Weighted-Average Grant Price [Roll Forward]      
Outstanding, beginning of period (in dollars per share) $ 30.84    
Restricted stock units grant price (in dollars per share) 52.70    
Vested (in dollars per share) 30.12    
Forfeited (in dollars per share) 38.77    
Outstanding, end of period (in dollars per share) $ 42.82 $ 30.84  
Aggregate intrinsic value [Abstract]      
Outstanding, beginning of period $ 39.6    
Outstanding, end of period 54.6 $ 39.6  
Cost of Product Sales [Member] | Continuing Operations [Member]      
Employee Service Share-based Compensation, Aggregate [Abstract]      
Total stock-based compensation expense 1.7 1.1 1.0
Research and Development [Member] | Continuing Operations [Member]      
Employee Service Share-based Compensation, Aggregate [Abstract]      
Total stock-based compensation expense 3.1 2.5 2.3
Selling, General and Administrative [Member] | Continuing Operations [Member]      
Employee Service Share-based Compensation, Aggregate [Abstract]      
Total stock-based compensation expense $ 18.4 $ 11.6 $ 14.1