Condensed Consolidated Statements of Operations (Unaudited) - USD ($) $ in Thousands		3 Months Ended		9 Months Ended
		Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Total revenues		$ 173,653	$ 149,434	$ 511,667	$ 367,064
Operating expenses:
Cost of product sales and contract manufacturing		73,232	44,503	220,449	125,449
Research and development		37,006	22,659	90,802	68,886
Selling, general and administrative		42,105	34,503	121,815	101,521
Income from operations		21,310	47,769	78,601	71,208
Other income (expense):
Interest income		701	637	1,229	1,593
Interest expense		(642)	(1,991)	(1,884)	(5,734)
Other income (expense), net		190	(101)	11	(387)
Total other income (expense), net		249	(1,455)	(644)	(4,528)
Income before provision for income taxes		21,559	46,314	77,957	66,680
Provision for income taxes		614	12,763	11,776	18,028
Net income		$ 20,945	$ 33,551	$ 66,181	$ 48,652
Net income per share - basic (in dollars per share)		$ 0.42	$ 0.81	$ 1.33	$ 1.19
Net income per share - diluted (in dollars per share)	[1]	$ 0.41	$ 0.68	$ 1.29	$ 1.03
Weighted-average number of shares - basic (in shares)		50,071,632	41,222,504	49,851,082	40,989,813
Weighted-average number of shares - diluted (in shares)		51,486,996	50,467,829	51,189,680	50,090,088
Product Sales [Member]
Revenues:
Total revenues		$ 133,269	$ 114,296	$ 389,115	$ 259,875
Contract Manufacturing [Member]
Revenues:
Total revenues		22,172	18,912	71,963	52,700
Contracts and Grants [Member]
Revenues:
Total revenues		$ 18,212	$ 16,226	$ 50,589	$ 54,489

[1] See "Earnings per share" footnote for details on calculation.