Condensed Consolidated Statements of Operations (Unaudited) - USD ($) $ in Thousands		3 Months Ended		6 Months Ended
		Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Total revenues		$ 220,200	$ 100,772	$ 338,014	$ 217,630
Operating expenses:
Cost of product sales and contract manufacturing		89,173	34,624	147,217	80,946
Research and development		24,745	25,751	53,796	46,227
Selling, general and administrative		39,506	31,868	79,710	67,018
Income from operations		66,776	8,529	57,291	23,439
Other income (expense):
Interest income		306	583	528	956
Interest expense		(1,008)	(1,805)	(1,242)	(3,743)
Other expense, net		(253)	(586)	(179)	(286)
Total other expense, net		(955)	(1,808)	(893)	(3,073)
Income before provision for income taxes		65,821	6,721	56,398	20,366
Provision for income taxes		15,677	2,105	11,162	5,265
Net income		$ 50,144	$ 4,616	$ 45,236	$ 15,101
Net income per share - basic (in dollars per share)		$ 1.00	$ 0.11	$ 0.91	$ 0.37
Net income per share - diluted (in dollars per share)	[1]	$ 0.98	$ 0.11	$ 0.89	$ 0.35
Weighted-average number of shares - basic (in shares)		49,896,124	41,013,764	49,738,980	40,871,540
Weighted-average number of shares - diluted (in shares)		51,162,909	50,078,594	51,039,195	49,899,291
Product Sales [Member]
Revenues:
Total revenues		$ 180,075	$ 63,610	$ 255,846	$ 145,579
Contract Manufacturing [Member]
Revenues:
Total revenues		23,613	16,160	49,791	33,788
Contracts and Grants [Member]
Revenues:
Total revenues		$ 16,512	$ 21,002	$ 32,377	$ 38,263

[1] See "Earnings per share" footnote for details on calculation.