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Fair value measurements (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Jan. 29, 2014
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Unobservable Input Reconciliation [Roll Forward]          
Balance, beginning of period       $ 13,185  
Expense included in earnings       1,350  
Settlements       (2,744)  
Balance, end of period   $ 11,791   11,791  
Convertible Senior Notes Due 2021 [Member]          
Unobservable Input Reconciliation [Roll Forward]          
Face amount of debt instrument $ 250,000        
Interest rate, stated percentage 2.875%        
Maturity date Jan. 15, 2021        
Fair value of the notes   359,500   359,500  
Evolva Holding SA 035 & Broad Spectrum Antiviral Platform [Member]          
Unobservable Input Reconciliation [Roll Forward]          
Change in fair value of contingent obligations     $ 100 (100) $ (300)
RSDL [Member]          
Unobservable Input Reconciliation [Roll Forward]          
Change in fair value of contingent obligations   $ 900 $ (2,300) $ 1,400 $ (1,000)