Consolidated Statements of Operations (Unaudited) - USD ($) $ in Thousands	3 Months Ended				9 Months Ended
	Sep. 30, 2016		Sep. 30, 2015		Sep. 30, 2016	Sep. 30, 2015
Revenues:
Product sales	$ 96,698		$ 117,512		$ 208,785	$ 204,563
Contract manufacturing	14,712		11,341		32,455	32,443
Contracts, grants and collaborations	31,504		29,525		95,879	92,541
Total revenues	142,914		158,378		337,119	329,547
Operating expenses:
Cost of product sales and contract manufacturing	39,560		35,240		93,025	73,083
Research and development	27,188		34,179		81,173	93,833
Selling, general and administrative	40,688		25,800		108,328	86,263
Income from operations	35,478		63,159		54,593	76,368
Other income (expense):
Interest income	358		104		764	459
Interest expense	(2,049)		(1,635)		(5,082)	(4,923)
Other income (expense), net	(234)		519		(176)	669
Total other expense, net	(1,925)		(1,012)		(4,494)	(3,795)
Income from continuing operations before provision for income taxes	33,553		62,147		50,099	72,573
Provision for income taxes	13,165		20,059		19,861	23,648
Net Income from continuing operations	20,388		42,088		30,238	48,925
Income (loss) from discontinued operations (net of tax)	952		(5,145)		(15,854)	(19,402)
Net income	$ 21,340		$ 36,943		$ 14,384	$ 29,523
Net income per share - basic:
Income from continuing operations (in dollars per share)	$ 0.50		$ 1.08		$ 0.75	$ 1.28
Income (loss) from discontinued operations (in dollars per share)	0.02		(0.14)		(0.40)	(0.51)
Net income per share - basic (in dollars per share)	0.52		0.94		0.35	0.77
Net income per share - diluted:
Income from continuing operations (in dollars per share)	0.43	[1]	0.90	[1]	0.68	1.11
Income (loss) from discontinued operations (in dollars per share)	0.02		(0.11)		(0.32)	(0.42)
Net income per share - diluted (in dollars per share)	$ 0.45	[1]	$ 0.79	[1]	$ 0.36	$ 0.69
Weighted-average number of shares - basic (in shares)	40,465,423		38,831,341		40,071,730	38,423,715
Weighted-average number of shares - diluted (in shares)	49,440,313		47,784,550		48,826,597	46,958,179

[1] See Note 8 "Earnings per share" for details on calculation.