Intangible assets, in-process research and development (Details) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Accumulated Amortization [Abstract]
Amortization	$ 1,651,000	$ 1,844,000	$ 5,337,000	$ 5,532,000
Intangible assets, weighted average useful life			78 months
Biodefense [Member]
Cost Basis [Abstract]
Intangible Assets, Beginning Balance			$ 57,099,000
Additions			0
Intangible Assets, Ending Balance	57,099,000		57,099,000
Accumulated Amortization [Abstract]
Accumulated Amortization, Beginning Balance			(16,343,000)
Accumulated Amortization, Ending Balance	(21,680,000)		(21,680,000)
Net book value of intangible assets	$ 35,419,000		$ 35,419,000