Consolidated Statements of Operations (Unaudited) - USD ($) $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2016		Jun. 30, 2015		Jun. 30, 2016	Jun. 30, 2015
Revenues:
Product sales	$ 58,546		$ 82,023		$ 130,252	$ 100,314
Contract manufacturing	10,156		8,859		17,743	21,102
Contracts, grants and collaborations	32,785		35,230		64,494	68,329
Total revenues	101,487		126,112		212,489	189,745
Operating expenses:
Cost of product sales and contract manufacturing	35,612		27,266		64,115	46,014
Research and development	35,347		40,941		69,501	79,643
Selling, general and administrative	44,148		36,453		83,932	70,946
Income (loss) from operations	(13,620)		21,452		(5,059)	(6,858)
Other income (expense):
Interest income	220		273		406	355
Interest expense	(1,509)		(1,628)		(3,033)	(3,288)
Other income, net	17		(497)		133	(397)
Total other expense, net	(1,272)		(1,852)		(2,494)	(3,330)
Income (loss) before provision for (benefit from) income taxes	(14,892)		19,600		(7,553)	(10,188)
Provision for (benefit from) income taxes	(3,945)		5,500		(597)	(2,769)
Net income (loss)	$ (10,947)		$ 14,100		$ (6,956)	$ (7,419)
Net income (loss) per share - basic	$ (0.27)		$ 0.37		$ (0.17)	$ (0.19)
Net income (loss) per share-diluted	$ (0.27)	[1]	$ 0.32	[1]	$ (0.17)	$ (0.19)
Weighted-average number of shares - basic (in shares)	40,202,821		38,480,754		39,872,738	38,216,524
Weighted-average number of shares - diluted (in shares)	40,202,821		47,410,413		39,872,738	38,216,524

[1] See Note 8 "Earnings per share" for details on calculation.