Consolidated Statements of Operations (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Revenues:
Product sales	$ 71,706	$ 18,291
Contract manufacturing	7,587	12,243
Contracts, grants and collaborations	31,709	33,099
Total revenues	111,002	63,633
Operating expenses:
Cost of product sales and contract manufacturing	28,503	18,748
Research and development	34,154	38,702
Selling, general and administrative	39,784	34,493
Income (loss) from operations	8,561	(28,310)
Other income (expense):
Interest income	186	82
Interest expense	(1,524)	(1,661)
Other income, net	116	100
Total other expense, net	(1,222)	(1,479)
Income (loss) before provision for (benefit from) income taxes	7,339	(29,789)
Provision for (benefit from) income taxes	3,348	(8,269)
Net income (loss)	$ 3,991	$ (21,520)
Net income (loss) per share - basic	$ 0.10	$ (0.57)
Net income (loss) per share-diluted	$ 0.10	$ (0.57)
Weighted-average number of shares - basic (in shares)	39,542,656	37,949,358
Weighted-average number of shares - diluted (in shares)	48,359,892	37,949,358