Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Cash flows from operating activities:
Net income	$ 62,870	$ 36,741	$ 30,259
Adjustments to reconcile to net cash provided by operating activities:
Stock-based compensation expense	15,848	12,829	11,238
Other Depreciation and Amortization	35,335	32,453	18,958
Deferred income taxes	3,464	16,493	13,858
Non-cash development expenses from joint venture	0	0	(347)
Change in fair value of contingent obligations	(10,599)	3,133	735
Write off of debt issuance costs	0	1,831	0
Impairment of in-process research and development	9,827	0	0
Impairment of long-lived assets	1,147	0	1,172
Bad debt expense	3,481	0	0
Excess tax benefits from stock-based compensation	(11,281)	(5,987)	(3,099)
Other	271	1,284	51
Changes in operating assets and liabilities:
Accounts receivable	(64,351)	21,405	35,456
Inventories	(11,262)	4,229	518
Income taxes	(3,550)	(4,711)	(7,179)
Prepaid expenses and other assets	2,319	(8,472)	(6,226)
Accounts payable	4,749	(9,279)	(551)
Accrued expenses and other liabilities	45	2,685	7
Accrued compensation	2,680	4,539	2,092
Provision for chargebacks	(8)	299	0
Deferred revenue	3,474	2,846	26
Net cash provided by operating activities	44,459	112,318	96,968
Cash flows from investing activities:
Purchases of property, plant and equipment	(44,812)	(30,673)	(42,021)
Acquisitions, net of acquired cash	(650)	(179,379)	(25,873)
Net cash used in investing activities	(45,462)	(210,052)	(67,894)
Cash flows from financing activities:
Proceeds from convertible debenture, net of debt issuance costs	0	241,588	0
Proceeds from borrowings on long-term indebtedness	2,000	1,000	62,000
Issuance of common stock subject to employee equity plans	25,961	14,078	6,848
Excess tax benefits from stock-based compensation	11,281	5,987	3,099
Principal payments on long-term indebtedness and line of credit	0	(62,000)	(62,774)
Contingent obligation payments	(5,693)	(1,579)	(348)
Purchase of treasury stock	(100)	(200)	(213)
Net cash provided by (used in) financing activities	33,449	198,874	8,612
Effect of exchange rate changes on cash and cash equivalents	(150)	21	(14)
Net increase (decrease) in cash and cash equivalents	32,296	101,161	37,672
Cash and cash equivalents at beginning of year	280,499	179,338	141,666
Cash and cash equivalents at end of year	312,795	280,499	179,338
Supplemental disclosure of cash flow information:
Cash paid during the year for interest	7,751	3,761	2,055
Cash paid during the year for income taxes	28,271	4,711	6,331
Supplemental information on non-cash investing and financing activities:
Purchases of property, plant and equipment unpaid at year end	$ 4,379	$ 5,394	$ 2,755