Consolidated Statements of Operations (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2015	Jun. 30, 2014	Jun. 30, 2015	Jun. 30, 2014
Revenues:
Product sales	$ 82,023	$ 78,269	$ 100,314	$ 114,036
Contract manufacturing	8,859	9,187	21,102	11,913
Contracts, grants and collaborations	35,230	22,869	68,329	38,260
Total revenues	126,112	110,325	189,745	164,209
Operating expenses:
Cost of product sales and contract manufacturing	27,266	34,507	46,014	53,504
Research and development	40,941	37,401	79,643	67,657
Selling, general and administrative	36,453	30,555	70,946	60,644
Income (loss) from operations	21,452	7,862	(6,858)	(17,596)
Other income (expense):
Interest income	273	31	355	71
Interest expense	(1,628)	(1,721)	(3,288)	(5,256)
Other income (expense), net	(497)	1,322	(397)	1,834
Total other income (expense)	(1,852)	(368)	(3,330)	(3,351)
Income (loss) before provision for (benefit from) income taxes	19,600	7,494	(10,188)	(20,947)
Provision for (benefit from) income taxes	5,500	2,465	(2,769)	(5,740)
Net income (loss)	$ 14,100	$ 5,029	$ (7,419)	$ (15,207)
Income (loss) per share - basic	$ 0.37	$ 0.13	$ (0.19)	$ (0.41)
Income (loss) per share - diluted	$ 0.32	$ 0.13	$ (0.19)	$ (0.41)
Weighted-average number of shares - basic (in shares)	38,480,754	37,416,554	38,216,524	37,137,015
Weighted-average number of shares - diluted (in shares)	47,410,413	38,333,425	38,216,524	37,137,015