CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (USD $) In Thousands	Total USD ($)	Revolving Credit Facility USD ($)	Term Loan and Revolving Credit Facility USD ($)	Series A Preferred Stock USD ($)	Thermo USD ($)	Subordinated Loans USD ($)	Convertible 8.0 Percent Notes USD ($)	Interest Payments for 8.00% Notes USD ($)	Acquisition USD ($)	Contingent Equity Agreement USD ($)	Thermo debt USD ($)	Contingent Consideration USD ($)	Legal Settlement USD ($)	Common Stock USD ($)	Common Stock Revolving Credit Facility USD ($)	Common Stock Series A Preferred Stock USD ($)	Common Stock Thermo	Common Stock Convertible 8.0 Percent Notes USD ($)	Common Stock Interest Payments for 8.00% Notes	Common Stock Acquisition	Common Stock Thermo debt	Common Stock Contingent Consideration	Common Stock Legal Settlement	Additional Paid-In Capital USD ($)	Additional Paid-In Capital Revolving Credit Facility USD ($)	Additional Paid-In Capital Term Loan and Revolving Credit Facility USD ($)	Additional Paid-In Capital Thermo USD ($)	Additional Paid-In Capital Subordinated Loans USD ($)	Additional Paid-In Capital Convertible 8.0 Percent Notes USD ($)	Additional Paid-In Capital Interest Payments for 8.00% Notes USD ($)	Additional Paid-In Capital Acquisition USD ($)	Additional Paid-In Capital Contingent Equity Agreement USD ($)	Additional Paid-In Capital Thermo debt USD ($)	Additional Paid-In Capital Contingent Consideration USD ($)	Additional Paid-In Capital Legal Settlement USD ($)	Accumulated Other Comprehensive Loss USD ($)	Retained Deficit USD ($)
Beginning Balances at Dec. 31, 2008	$ 445,397													$ 14										$ 480,097												$ (6,304)	$ (28,410)
Beginning Balances (in shares) at Dec. 31, 2008														136,606
Net issuance of restricted stock awards and recognition of stock-based compensation (in shares)														7,112
Net issuance of restricted stock awards and recognition of stock-based compensation	10,341																							10,341
Contribution of services	337																							337
Warrants issued						5,215																						5,215
Conversion of convertible securities to equity (in shares)															10,000	126,174		10,175
Conversion of convertible securities to equity		7,800	180,052	13			10,474								1	13		1							7,799	180,052			10,473
Issuance of common stock																	1,391		246
Issuance of common stock					1,000																						1,000
Issuance of common stock in relation to Acquisition (in shares)																				6,298
Issuance of common stock in relation to Acquisition									5,500																						5,500
Return of common stock under share loan facility (in shares)																			(6,868)
Return of common stock under share loan facility
Other comprehensive (loss) income	4,586																																			4,586
Net loss	(74,923)																																				(74,923)
Ending Balances at Dec. 31, 2009	595,792													29										700,814												(1,718)	(103,333)
Ending Balances (in shares) at Dec. 31, 2009														291,134
Net issuance of restricted stock awards and recognition of stock-based compensation (in shares)														4,183
Net issuance of restricted stock awards and recognition of stock-based compensation	1,270													1										1,269
Contribution of services	168																							168
Warrants issued										11,940																						11,940
Conversion of convertible securities to equity (in shares)																		3,246			2,526
Conversion of convertible securities to equity							3,415				2,426																		3,415				2,426
Warrants exercised associated with the 8.00% Notes (in shares)														8,110
Warrants exercised associated with the 8.00% Notes	15,234													1										15,233
Issuance of common stock in relation to Acquisition (in shares)																						760
Issuance of common stock in relation to Acquisition												1,190																						1,190
Other comprehensive (loss) income	1,450																																			1,450
Net loss	(97,467)																																				(97,467)
Ending Balances at Dec. 31, 2010	535,418													31										736,455												(268)	(200,800)
Ending Balances (in shares) at Dec. 31, 2010														309,959
Net issuance of restricted stock awards and recognition of stock-based compensation (in shares)														994
Net issuance of restricted stock awards and recognition of stock-based compensation	2,017																							2,017
Contribution of services	319																							319
Warrants issued										5,955																						5,955
Conversion of convertible securities to equity (in shares)																		773
Conversion of convertible securities to equity							942																						942
Warrants exercised associated with the 8.00% Notes (in shares)														575
Warrants exercised associated with the 8.00% Notes	1,064																							1,064
Issuance of common stock																			1,300				566
Issuance of common stock								572					644																	572					644
Issuance of common stock in relation to Acquisition (in shares)																						1,857
Issuance of common stock in relation to Acquisition												1,827																						1,827
Issuance of warrants and beneficial conversion feature associated with 5.0% Notes	24,868																							24,868
Issuance of nonvoting stock to Thermo for contingent equity draws (in shares)														36,606
Issuance of nonvoting stock to Thermo for contingent equity draws	17,750													4										17,746
Issuance of stock through employee stock purchase plan (in shares)														428
Issuance of stock through employee stock purchase plan	175																							175
Other comprehensive (loss) income	(2,832)																																			(2,832)
Net loss	(54,924)																																				(54,924)
Ending Balances at Dec. 31, 2011	$ 533,795													$ 35										$ 792,584												$ (3,100)	$ (255,724)
Ending Balances (in shares) at Dec. 31, 2011														353,058